Reversed-phase ion-pair liquid chromatography for the purification of 177Lu

Abstract

This separation study employed reversed-phase ion-pair liquid chromatography, which uses a silica gel containing polar groups such as nitrile and alkyl siloxane as a stationary phase to prepare high-purity 177 Lu from an enriched Yb target. Adequate mobile phases were identified for the selected columns, and the reproducibility of separation was assessed during a continuous use of the columns. No-carrier added (nca) 177 Lu was perfectly separated from 10 mg of the Yb 2 O 3 target that had been neutron-irradiated in the HANARO reactor, and the separation performance of the column was unaffected after 10 repeated separations. The results of this study are expected to be useful when applied to produce nca 177 Lu of a few hundred mCi using a several milligram Yb target, or an additional purification stage to produce curies-level 177 Lu with bulk a Yb 2 O 3 target.

Branched-Chain-Induced Host–Guest Assembly in Covalent-Organic Frameworks for Efficient Separation of No-Carrier-Added 177Lu

“…In the past decades, several strategies have been developed to separate NCA 177 Lu from neutron-irradiated 176 Yb target . Although relevant production technologies can yield barely adequate NCA 177 Lu, two or three stages are always required . Actually, unsatisfactory 177 Lu recovery, long processing time, and plenty of liquid waste of current radiochemical separation methods cannot meet the sharp increase of the radionuclide supply with the rapid development of 177 Lu TRT. − Thus, designing new separation methods with excellent efficiency is of great significance to deal with the near-future 177 Lu shortage.…”