Reversed phase ion-pairing HPLC-ICP-MS for analysis of organophosphorus chemical warfare agent degradation products

Environmental application of elemental speciation analysis based on liquid or gas chromatography hyphenated to inductively coupled plasma mass spectrometry—A review

“…The sensitivity of bromine detection is additionally limited by the fact that spectral interferences from Ar (e.g. ArK, Ar 2 H) or adjacent Kr isotopes ( 80 Kr, 81 Kr) might contribute significantly to the background signal of the two available isotopes 79 Br and 81 Br (both exhibit an isotopic abundance of approximately 50%).…”

“…EMPA, IMPA, MPA IP-RP-HPLC-ICP-MS 0.14-0.27 g L −1 (as compounds) Extracts from spiked soil; water samples [81] Iodate sediment and water would remain elevated for still a long time. Generally, sample preparation was and still is a major issue in this topic [19].…”

“…In another application, residues of P-containing chemical warfare agents in soils were studied by ion pairing RP-HPLC-ICP-MS [81]. Three organo-phosphorus chemical warfare degradation products, namely ethyl methylphosphonic acid (EMPA), the major hydrolysis product of VX, isopropyl methylphosphonic acid (IMPA), the major hydrolysis product of Sarin, and methylphosphonic acid (MPA), the final hydrolysis product of both were separated.…”

Umweltanalytik mit Ionenchromatografie: Status quo und Zukunftsperspektiven

“…Zum hochempfindlichen Nachweis dieser Hydrolyseprodukte in Umweltmedien wurde kürzlich eine IPC-Methode vorgestellt, die einen langkettigen Ionenpaarbildner (Myristylammoniumbromid) zur Trennung an einer Alltech Alltima RP-C 18 -Phase einsetzt. Die ICP-MS-Nachweisgrenzen bewegen sich im Bereich von 0,14-0,26 µg·L -1 (Richardson et al 2006).…”

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

“…Richardson and Caruso published two papers dealing with the analysis of organophosphorus nerve agent degradation products, using either reversed-phase ion pairing HPLC 135 or GC 136 after trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBDMS) derivatization for their separation. Phosphorus-specific detection during HPLC experiments has been carried out using collision cell ICP-MS and helium as the cell gas.…”