Reversed-phase liquid chromatography of lisinopril conformers

Bouabdallah, Sondes; Trabelsi, H.; Bouzouita, K; Sabbah, S.

doi:10.1016/s0165-022x(02)00140-9

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…Careful monitoring of all parameters is required. Our experiments using the recommended column and eluant showed that alteration of pH by 0.2 units, a 2 -3% decrease in the acetonitrile concentration, and a decrease in temperature by a few degrees could lead to broadening of the lisinopril peak, sometimes with splitting, pointing to the existence of multiple forms of lisinopril in solution, consistent with data reported in [3,10].…”

Section: Resultssupporting

confidence: 91%

Analysis of the angiotensin-converting enzyme inhibitors perindopril, lisinopril, and quinapril by HPLC

Khomushku¹,

Жлоба²,

Puchnin³

et al. 2011

Pharm Chem J

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A unified HPLC method for analyzing the angiotensin-converting enzyme (ACE) inhibitors perindopril, lisinopril, and quinapril using a single column with a nonpolar phase based on octadecylsilica gel and a universal eluant (a mixture of acetonitrile and aqueous heptanesulfonic acid and triethylamine) is described; this method significantly decreases workload and the cost of analysis. The method can be used for the analysis of substances and different therapeutic formulations containing ACE inhibitors.

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Section: Resultssupporting

confidence: 91%

Analysis of the angiotensin-converting enzyme inhibitors perindopril, lisinopril, and quinapril by HPLC

Khomushku¹,

Жлоба²,

Puchnin³

et al. 2011

Pharm Chem J

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“…The result obtained is the normal behavior for most compounds in the reversed phase mode, i. e. decreasing retention with increasing temperature. The same behavior was noted in a previous study using a column fabricated by a standard organosilanization protocol [15]. Therefore, as demonstrated in an earlier study of hydride type phases, they perform under most reversed-phase conditions like typical commercial C18 materials [16].…”

Section: Reversed Phasesupporting

confidence: 82%

“…Linsinopril and its analogs have been analyzed by reversed-phase liquid chromatography [15]. Therefore some of its chromatographic behavior is reasonably wellknown on conventional C18 stationary phases.…”

Section: Reversed Phasementioning

confidence: 99%

Temperature effects on solute retention for hydride‐based stationary phases

Pesek

Matyska

Hearn

et al. 2007

J of Separation Science

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The effect of solute retention is investigated for two hydride-based stationary phases: bidentate C18 and cholesterol. Several small molecules and peptides are used as solutes. In the reversed-phase mode, most compounds have the expected temperature behavior, i.e. decreasing retention with increasing temperature. Two analogs of the drug lisinopril do exhibit the opposite behavior on the cholesterol column; increasing retention with increasing temperature. In the aqueous normal phase (ANP) mode, more compounds, particularly certain peptides, have this unusual retention behavior with respect to temperature. These preliminary studies indicate that as ANP retention becomes stronger, there is a greater possibility of observing increasing retention with increasing temperature.

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“…As a result, the goal was to obtain a symmetrical chromatographic peak of lisinopril, using a mobile phase with pH 7-7.5 without using ion pair reagents and column heating, even though previous studies [29,30] demonstrated that these factors cause isomerization, i.e. rotamerization of lisinopril leading to splitting and/or tailing of the obtained chromatographic peak.…”

Section: Methods Development and Optimizationmentioning

confidence: 99%

Development and validation of a fast, simple, cost-effective and robust HPLC method for lisinopril determination in solid pharmaceutical dosage forms

Stoimenova¹,

Piponski²,

Serafimovska³

et al. 2017

Maced. J. Chem. Chem. Eng.

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A fast, simple, cost-effective and robust chromatographic method was developed and validated for determination of the antihypertensive drug lisinopril dihydrate in tablets under routine operational conditions, without ion-pair reagents, high column temperatures and an acidic mobile phase. Taking into consideration all four different pKa values of lisinopril, the separation was optimized using the C18 column (end-capped, 150 mm × 4.6 mm 5 µm) and a mobile phase composed of methanol and ammonium (or potassium) dihydrogen phosphate buffer (pH 7.2) with a flow rate of 1.1 ml/min, UV detection at 214 nm and a temperature of 40 °C. These optimized conditions led to the production of a single and symmetrical peak for lisinopril. This mobile phase is suitable for different HPLC columns, which makes it appropriate for industrial quality control laboratories. The developed method was validated, showing excellent validation results and the possibility to be implemented for the determination of lisinopril in combined dosage forms with other active substances.

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Reversed-phase liquid chromatography of lisinopril conformers

Cited by 19 publications

References 29 publications

Analysis of the angiotensin-converting enzyme inhibitors perindopril, lisinopril, and quinapril by HPLC

Analysis of the angiotensin-converting enzyme inhibitors perindopril, lisinopril, and quinapril by HPLC

Temperature effects on solute retention for hydride‐based stationary phases

Development and validation of a fast, simple, cost-effective and robust HPLC method for lisinopril determination in solid pharmaceutical dosage forms

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