Reversibility of rocuronium-induced profound neuromuscular block with sugammadex in younger and older patients

Abstract

Sugammadex can adequately restore neuromuscular function in older patients, although a longer time is required to recover from profound rocuronium-induced neuromuscular block than in younger patients.

Komentarz do artykułu „Blokada nerwowo-mięśniowa u osób w wieku podeszłym”

“…This result was attributed to decreased circulatory system dynamics, and the resulting delay in drug distribution present in elderly people. Similar conclusions were reached by Suzuki et al [8] who compared the return period for muscle strength after using sugammadex in patients between 20 and 50 years of age, as well as those older than 70, and Turkish authors who assessed the effect of age on muscle strength return after using sugammadex in patients between 65 and 74, as well as those older than 75 years of age [9]. In all of the cited articles, age did not affect the presence of side effects, while the medication was considered to be well-tolerated.…”

Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study

“…No significant differences were noted between the groups regarding the incidence of residual neuromuscular blockade on admission to the PACU and 1 h later, or on the occurrence of adverse respiratory events. The results of Suzuki and colleagues [29] suggest that appropriate use of sugammadex is associated with the absence of both residual neuromuscular blockade and severe respiratory events in the PACU. However, there have been reports of residual neuromuscular blockade in specific clinical situations.…”

Reversal of neuromuscular block in companion animals

“…However, sugammadex provides the anaesthetist with the opportunity to improve surgical access with profound NMB and rapidly reverse NMB at the end of surgery during caesarean section (Williamson et al 2011;Hamada & Kayashima 2013). Although reversal of profound NMB in older patients was delayed compared to younger patients, TOF ratio of 0.9 was still reached in <four minutes in the older patients (Suzuki et al 2011). Sugammadex prevented PORC during recovery in morbidly obese patients, while neostigmine failed to guarantee TOF ratio >0.9 during recovery (Gaszynski et al 2012).…”