2023
DOI: 10.1101/2023.12.22.573005
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Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

Ioana Sava,
Luther J. Davis,
Sally R. Gray
et al.

Abstract: Regulation of the luminal pH of late endocytic compartments in continuously fed mammalian cells is poorly understood. Using normal rat kidney fibroblasts, we investigated the reversible assembly/disassembly of the proton pumping V-ATPase when endolysosomes are formed by kissing and fusion of late endosomes with lysosomes and during the subsequent reformation of lysosomes. We took advantage of previous work showing that sucrosomes formed by the uptake of sucrose are swollen endolysosomes from which lysosomes ar… Show more

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