1984
DOI: 10.1530/acta.0.107s060
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Reversible azoospermia induced by the anabolic steroid 19-nortestosterone

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Cited by 28 publications
(52 citation statements)
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“…The favourable combination of intramuscular DMPA injections combined with androgen injections showed its potential contraceptive efficacy by suppressing sperm concentrations to 51610 6 /ml in the majority of men 38 . Especially the additive effect of the longacting synthetic androgen 19-nortestosterone seemed promising, as this anabolic steroid had already shown contraceptive potency 39 . Encouraged by a study demonstrating that threeweekly injections of 200 mg 19-nortestosterone together with injections of 250 mg of DMPA achieved azoospermia in eight out of 12 volunteers, while three more had only single sperm in the ejaculate and one showed severe oligozoospermia 40 , the WHO initiated a multi-centre trial in Indonesia to directly compare the administration of DMPA combined with either testosterone enanthate or 19-nortestosterone 41 .…”
Section: E P O T -M E D R O X Y P R O G E S T E R O N E a C E T A T Ementioning
confidence: 99%
“…The favourable combination of intramuscular DMPA injections combined with androgen injections showed its potential contraceptive efficacy by suppressing sperm concentrations to 51610 6 /ml in the majority of men 38 . Especially the additive effect of the longacting synthetic androgen 19-nortestosterone seemed promising, as this anabolic steroid had already shown contraceptive potency 39 . Encouraged by a study demonstrating that threeweekly injections of 200 mg 19-nortestosterone together with injections of 250 mg of DMPA achieved azoospermia in eight out of 12 volunteers, while three more had only single sperm in the ejaculate and one showed severe oligozoospermia 40 , the WHO initiated a multi-centre trial in Indonesia to directly compare the administration of DMPA combined with either testosterone enanthate or 19-nortestosterone 41 .…”
Section: E P O T -M E D R O X Y P R O G E S T E R O N E a C E T A T Ementioning
confidence: 99%
“…Infertility is a common effect of anabolic steroid use and this has been utilised by the WHO in the research for a male contraceptive (Schurmeyer et al 1984, WHO Task Force on Methods for the Regulation of Male Fertility 1990). A reduction in testicular volume can be observed.…”
Section: Genitourinarymentioning
confidence: 99%
“…They have been extensively studied in both animals and humans for the last five decades (Birch 1950;Engel et al 1958;Dimick et al 1961;Schu¨rmeyer et al 1984;Belkien et al 1985;Dumasia et al 1989;Minto et al 1997;Bhasin et al 2003). They are also obligatory intermediates in estrogen biosynthesis, in both animals and man (Short 1961;Skinner and Akhtar 1969;Berkowitz et al 1984;Courtot et al 1984;Bergink et al 1985;Dumasia et al 1989;Garrett et al 1991).…”
Section: Resultsmentioning
confidence: 99%
“…Since then, the pharmaceutical industry has produced norsteroids for human, and animal, substitutive (hypogonadism), complementary (osteoporosis and haemological diseases) or contraceptive treatment (Frankle and Leffers 1992;Mauvais-Jarvis 1984;Schu¨rmeyer et al 1984;Segaloff 1963;Wilson 1988).…”
Section: Origin Of Endogenous Nandrolone and Norsteroidsmentioning
confidence: 99%