Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia

Lakhwani, Sunil; Raya, José‐María; González-Brito, G.; Álvarez‐Argüelles, Hugo; Brito, M.L.; Hernández-Nieto, L

doi:10.1097/pat.0b013e3283489087

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Cited by 4 publications

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“…The most common etiology of BM necrosis is the underlying malignant disease, particularly hematologic malignancies [ 3 , 4 ]. Rarely, it may be caused by chemotherapy such as imatinib, all-trans-retinoic acid (ATRA), or arsenic trioxide, as well as immunotherapeutic agents [ 5 - 9 ]. In addition, granulocyte-colony stimulating factor (G-CSF), administered after chemotherapy to aid hematologic recovery, has been associated with the development of BM necrosis [ 10 ].…”

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confidence: 99%

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

et al. 2020

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Section: To the Editormentioning

confidence: 99%

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

et al. 2020

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Spinal bone marrow necrosis with vertebral compression fracture: differentiation of BMN from AVN

et al. 2014

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Bone marrow necrosis (BMN) is a rare malignancy-associated hematologic disorder characterized by necrosis of myeloid and stromal marrow elements with preservation of cortical bone. Overlap between the imaging appearances of BMN and avascular necrosis (AVN) raises the potential for diagnostic confusion. We report a case of BMN presenting with a traumatic multi-level vertebral body collapse, and finding that may potentially confound distinction between the two entities. We discuss important pathophysiologic, clinical, and radiologic differences between BMN and AVN with emphasis on features important in the differential diagnosis.

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Pain crisis complicating severe bone marrow necrosis during induction for acute promyelocytic leukaemia

Goodall,

Tedjaseputra,

Hui

et al. 2024

Pathology

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Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia

Cited by 4 publications

References 7 publications

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

Spinal bone marrow necrosis with vertebral compression fracture: differentiation of BMN from AVN

Pain crisis complicating severe bone marrow necrosis during induction for acute promyelocytic leukaemia

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