Reversible dementia in systemic lupus erythematosus without antiphospholipid antibodies or cerebral infarction

Lee, S. I.; Jeon, Hyun Sun; Yoo, Wan Hee

doi:10.1007/s00296-003-0405-1

Cited by 10 publications

(1 citation statement)

References 27 publications

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“…To our knowledge, no cases of elderly NPSLE patients with cognitive dysfunction have shown complete improvement. One study reported that immunosuppressive therapy using corticosteroids and IVCY was effective in the treatment of young SLE patients with cognitive dysfunction ( 18 ). Given that IVCY following intravenous pulse therapy with methylprednisolone as an induction treatment is more effective than corticosteroids monotherapy for NPSLE patients ( 19 ), IVCY is crucial for treating NPSLE.…”

Section: Discussionmentioning

confidence: 99%

Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy

et al. 2018

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A 70-year-old Japanese woman presented to our hospital with gait disturbance and cognitive dysfunction. Since she had arthritis, lymphopenia, hypocomplementemia, and anti-nuclear and anti-double-stranded DNA antibodies, she was diagnosed with systemic lupus erythematosus (SLE). T2-weighted magnetic resonance imaging revealed bilateral hyperintensities in the putamen. Based on her cognitive impairment, muscle rigidity, and high levels of interleukin-6 in the cerebrospinal fluid, we believed she had developed a complication of a neuropsychiatric disease and administered corticosteroids and intravenous cyclophosphamide therapy. Her cognitive function fully recovered, and her gait disturbance improved. Attending to cognitive impairment in elderly SLE patients is necessary.

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Section: Discussionmentioning

confidence: 99%

Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy

et al. 2018

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Polymorphism of the interleukin‐1 receptor antagonist gene: A factor in susceptibility to rheumatoid arthritis in a Spanish population

Carreira¹,

Gonzalez-Crespo²,

Ciruelo³

et al. 2005

Arthritis & Rheumatism

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Objective. To assess whether an interleukin-1 receptor antagonist gene (IL1RN) polymorphism is associated with disease susceptibility and/or severity in a Spanish population of patients with rheumatoid arthritis (RA).Methods. An 86-bp variable-number tandem repeat polymorphism within IL1RN intron 2 was analyzed by polymerase chain reaction in genomic DNA obtained from 247 unrelated patients with RA (group A) and 287 healthy control subjects. The polymorphism analysis was repeated in a second group of 194 patients with RA (group B). Clinical information from patients in group A was used to compare activity and severity data in patients stratified according to the different alleles or genotypes. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to determine the strength of the association of the different alleles or genotypes with RA activity or severity.Results. In the control group, the allelic frequencies were 76% for IL1RN*1 (4 repeats), 21% for IL1RN*2 (2 repeats), 3% for IL1RN*3 (5 repeats), and 0.3% for IL1RN*4 (3 repeats). In group A patients with RA, both the frequency (OR 1.47, 95% CI 1.1-1.96, P ‫؍‬ 0.007) and carriage rate (OR 1.6, 95% CI 1.1-2.2, P ‫؍‬ 0.01) of allele IL1RN*2 were significantly increased. The increased frequency of IL1RN*2 was confirmed in group B patients with RA (OR 1.44, 95% CI 1.1-1.97, P ‫؍‬ 0.01). In patients with RA, homozygosity for IL1RN*2 was associated with an increased number of affected articular areas during the first year of followup but not with other parameters of disease activity or severity.Conclusion. Our results suggest that IL1RN has a role in determining susceptibility to RA in the Spanish population.

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Severe Cognitive Dysfunction in a Patient with Polyendocrinopathy

Aminorroaya²,

Amini³

et al. 2007

Exp Clin Endocrinol Diabetes

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Reversible dementia in systemic lupus erythematosus without antiphospholipid antibodies or cerebral infarction

Cited by 10 publications

References 27 publications

Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy

Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy

Polymorphism of the interleukin‐1 receptor antagonist gene: A factor in susceptibility to rheumatoid arthritis in a Spanish population

Severe Cognitive Dysfunction in a Patient with Polyendocrinopathy

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