Reversible "Fanconi Syndrome" Caused by Degraded Tetracycline

Frimpter, George W.

doi:10.1001/jama.1963.03700150065010

Cited by 152 publications

(38 citation statements)

References 3 publications

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“…It has been known since 1960 that breakdown products of tetracyclines used after their shelf life are toxic and cause Fanconi syndrome (4). In 1963, Gross (5) and Frimpter et al (6) identified the major degradation products present in the outdated tetracycline capsules. Subsequent animal studies by Benitz and Diermeier (7) evaluated the toxicity of three separate tetracycline degradation products, demonstrating that epianhydrotetracycline was the most toxic.…”

Section: Introductionmentioning

confidence: 99%

ASN Clinicopathologic Conference

Singh

Racusen

2011

Clinical Journal of the American Society of Nephrology

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Section: Introductionmentioning

confidence: 99%

ASN Clinicopathologic Conference

Singh

Racusen

2011

Clinical Journal of the American Society of Nephrology

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“…Regarding about the nature of the drugs beyond the expiry date, most of the drugs merely lose their potency not toxic except for tetracycline. Few reports show the association of renal tubular dysfunction and consumption of expired tetracyclines [7,8]. At present, stability and the formulation have been improved to overcome the toxicity [9,10].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Knowledge and Practice Toward Disposal of Expired Drugs Among Medical Professionals in Chennai - A Cross-Sectional Prospective Study

Arunachalam

et al. 2017

Asian J Pharm Clin Res

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Objective: Proper disposal of expired drugs can avoid drug abuse, drug diversion, environmental contamination, and accidental poisoning by children and animals. Our study was aimed to assess the knowledge and practice toward disposal of expired drugs among medical professionals. Methods:After obtaining verbal consent, a self-administered pretested questionnaire was given to tutors, junior resident, senior resident, assistant professors, associate professors, and professors of Tagore Medical and Dental College and Hospital. The questionnaire has two parts; part one includes demographic details of the study participants, and part two comprises questions, regarding their awareness, knowledge, and practice toward disposal of expired drugs. Data were described as a percentage and analyzed using Sigma Graphpad prism version-5 and Microsoft Excel 2007.Results: A total of 156 medical professionals participated in the study. Among them, 85 were males and 71 were females, whereas 123 (78.8%) were medical and 33 (21.2%) were dental faculties. It was observed that 74.3% of respondents check the expiry date of the drug always and 62.2% said the drug loses its therapeutic effect after the expiry date. Analyzing the method to dispose the expired drugs, 77.6% throw in their household dustbins, 2.6% flush in toilets, 19.2% return to the pharmacist, and 4.5% bury. One-fourth of the medical professionals not aware about environmental hazards due to improper disposal and also believe they do not cause any harm. 64% of preferred pharmacist would be the appropriate person to inform about proper disposal of drugs. Conclusion:This study shows lacunae in the knowledge and practice about proper disposal of expired drugs and recommends discussion regarding improper disposal and its consequences in various health programs.

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“…Some medications may instruct the user to discard in the toilet, if there is any leftover. This method may not be any safer than throwing in the trash, because it still is contaminating water supply [12]- [20].…”

Section: Abstract-anti-biotics Tetracycline Hydrochloride Expired Dmentioning

confidence: 99%

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

2017

IJACEBS

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Reversible "Fanconi Syndrome" Caused by Degraded Tetracycline

Cited by 152 publications

References 3 publications

ASN Clinicopathologic Conference

ASN Clinicopathologic Conference

Assessment of Knowledge and Practice Toward Disposal of Expired Drugs Among Medical Professionals in Chennai - A Cross-Sectional Prospective Study

Natural Bio-Polymer and Pharmaceutical Drugs in Textile Processing

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