Reversible flocculation of nanoparticles by a carbamate surfactant

Hellström, Anna-Karin; Bordes, Romain

doi:10.1016/j.jcis.2018.10.057

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Some metal carbamato complexes have been investigated as additives to modify the physico-chemical properties of liquid systems. In this regard, bis-carbamates based on N,N-di(propylamino)dodecylamine produce under alkaline conditions a stable sodium bis-carbamate that is able to act as a surfactant [383,384]. This system is "switchable," as it can be reversed by heating or bubbling N 2 .…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in the Chemistry of Metal Carbamates

et al. 2020

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Following a related review dating back to 2003, the present review discusses in detail the various synthetic, structural and reactivity aspects of metal species containing one or more carbamato ligands, representing a large family of compounds across all the periodic table. A preliminary overview is provided on the reactivity of carbon dioxide with amines, and emphasis is given to recent findings concerning applications in various fields.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in the Chemistry of Metal Carbamates

et al. 2020

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“…Of note, Nanosac could be collected and washed through low-speed centrifugation (2,000 rcf), despite the small size. The ease of collection may be attributable to the formation of floccules, reversible aggregates of NPs, − by charge neutralization of NP surface during the etching process (Supporting Figure 5). After MSN a /siRNA/pD was treated with cationic ammonium fluoride (2 M HF/8 M NH 4 F, pH 5) for the removal of MSN, the NPs assumed near neutral charges of 10.3 ± 0.5 mV (in the first wash) and 0.027 ± 0.91 mV (in the second wash), forming floccules with an average size of 1401.7 ± 80.4 nm and 558.5 ± 31.7 nm, respectively.…”

Section: Resultsmentioning

confidence: 99%

Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors

et al. 2021

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For systemic delivery of small interfering RNA (siRNA) to solid tumors, the carrier must circulate avoiding premature degradation, extravasate and penetrate tumors, enter target cells, traffic to the intracellular destination, and release siRNA for gene silencing. However, existing siRNA carriers, which typically exhibit positive charges, fall short of these requirements by a large margin; thus, systemic delivery of siRNA to tumors remains a significant challenge. To overcome the limitations of existing approaches, we have developed a carrier of siRNA, called “Nanosac”, a noncationic soft polyphenol nanocapsule. A siRNA-loaded Nanosac is produced by sequential coating of mesoporous silica nanoparticles (MSNs) with siRNA and polydopamine, followed by removal of the sacrificial MSN core. The Nanosac recruits serum albumin, co-opts caveolae-mediated endocytosis to enter tumor cells, and efficiently silences target genes. The softness of Nanosac improves extravasation and penetration into tumors compared to its hard counterpart. As a carrier of siRNA targeting PD-L1, Nanosac induces a significant attenuation of CT26 tumor growth by immune checkpoint blockade. These results support the utility of Nanosac in the systemic delivery of siRNA for solid tumor therapy.

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“…Determination of the PCD potential of nanoparticles (Yellow 74) in the presence of Y12‐amine at pH 12 was performed using a PCD 02 particle charge detector (Mütek) and is described in detail elsewhere (Hellström and Bordes, ; Wäsche et al, ). Briefly, in the PCD device, particles in suspension are introduced in a measuring cell and two gold electrodes are integrated in the container wall for the potential measurement.…”

Section: Methodsmentioning

confidence: 99%

Carbamate Chemistry at Interfaces: Practical Considerations and Challenges of Studying Amine Surfactants

Hellström

Nordstierna

Bordes

2019

J Surfact & Detergents

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It is well known that CO2 reacts with primary and secondary amines in aqueous solutions and forms carbamates. This reaction can have consequences when studying the self‐assembly of amines. In this article, we discuss the practical challenges when working with an alkyl Y‐shaped amine (Y12‐amine) and demonstrate how the formation of carbamate species influences the physicochemistry of the amine‐based surfactant. A drift in dynamic surface tension was observed for Y12‐amine at pH above pKa due to the reaction with the naturally occurring CO2 from the atmosphere. The drift in dynamic surface tension was more pronounced at pH above pKa, than at and below pKa. Furthermore, the drift in dynamic surface tension of Y12‐amine at pH 12 also affected the surfactant's critical micelle concentration (CMC). CMC of Y12‐amine determined by the pendant drop at the air/water interface was almost five times higher than at the N2/water interface. The latter result was in agreement with the one determined by monitoring the change in chemical shift of 1H NMR in a N2 atmosphere. Moreover, it was also shown that the adsorption of the amine at different interfaces influences carbamate formation.

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Reversible flocculation of nanoparticles by a carbamate surfactant

Cited by 11 publications

References 24 publications

Recent Advances in the Chemistry of Metal Carbamates

Recent Advances in the Chemistry of Metal Carbamates

Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors

Carbamate Chemistry at Interfaces: Practical Considerations and Challenges of Studying Amine Surfactants

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