Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model

Abstract

Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.

Efficacy and Mechanisms of Gastric Volume-Restriction Bariatric Devices

“…Since so-called restrictive procedures are technically simple, there have been several devices designed to treat obesity by reducing gastric volume, apart from traditional gastric banding devices, in either laboratory or clinical settings. Our group developed a restrictive device (referred to as Gastric Sleeve Implant, GSI), which is designed to be laparoscopically implantable and removable ( Guo et al, 2011 , 2014 ) as shown in Figure 1B . When placed loosely on the outside (serosa) of the stomach, the device generates a sleeve-shaped pouch similar to sleeve gastrectomy (SG) but avoids the irreversibility of the SG because it does not require stapling or gastrectomy.…”

“…When the stomach is empty, GSI does not compress the stomach, which reduces the risk of device migration or tissue necrosis. GSI also has two C-rings to prevent the distension of the sleeve ( Guo et al, 2011 , 2014 ). The GSI is safe, effective and has been proven removable in animals ( Guo et al, 2011 , 2014 ).…”

“…GSI also has two C-rings to prevent the distension of the sleeve ( Guo et al, 2011 , 2014 ). The GSI is safe, effective and has been proven removable in animals ( Guo et al, 2011 , 2014 ). In a canine model, the excess weight loss reached 75% at 12 weeks after procedure but returned to 22% at 6 months after the removal of the device ( Guo et al, 2014 ).…”

Nutritional Weight Loss Therapy with Cooked Bean Powders Regulates Serum Lipids and Biochemical Analytes in Overweight and Obese Dogs

“…Similarities between dogs and humans with obesity associated comorbidities also exist for osteoarthritis, diabetes, nephropathy, cancer, and dyslipidemia [4][5][6][7]. Dogs represent an advanced translational model for cancer treatment [8,9] and other disease management therapies [10][11][12] and have been used extensively to evaluate surgical methods such as endoscopic pyloric suturing [13], reversible gastric restriction implants [14], and gastric bypass techniques [15]. Additionally, dogs have been shown to be successful models for evaluating protein intake, solving the nutritional mysteries behind pellagra and rickets [16] as well as evaluating effects of diet on brain physiology [17].…”