Reversible leukoencephalopathy caused by 2 rodenticides bromadiolone and fluroacetamide

Abstract

Rationale: With the easy access, rodenticide poisoning has been a public health problem in many countries. Characteristics of central nervous system (CNS) lesions induced by rodenticides are scarcely reported. Patient concerns: We presented a case of a 40-year-old man with seizure and consciousness disorder, coagulation dysfunction, and symmetric lesions in white matter and corpus callosum. Diagnosis: He was diagnosed with rodenticide poisoning due to bromadiolone and fluoroacetamide. Interventions: He was treated with vitamin K, hemoperfusion, acetamide, and calcium gluconate. Outcomes: His leukoencephalopathy was reversed rapidly with the improvement of clinical symptoms. Lessons: This report presented the impact of rodenticide poisoning on CNS and the dynamic changes of brain lesions, and highlighted the importance of timely targeted treatments.

Developmental dyslexia genes are selectively targeted by diverse environmental pollutants

“…Two out of the 7 rodenticides examined exhibited significant biases against dyslexia risk genes. Rodenticide poisoning could result in symmetrical lesions in the white matter and corpus callosum of the brain, leading to cognitive impairment [ 56 ]. Our findings suggest that different pesticides have distinct mechanisms of action in the pathogenesis of brain nerves, which could damage the brain by altering gene expression, inducing oxidative stress, and impairing mitochondrial function.…”