Reversible myocardial depression after massive catecholamine release from a pheochromocytoma

Quezado, Zenaide M.N.; Hr, Keiser; Mm, Parker

doi:10.1097/00003246-199204000-00022

Cited by 56 publications

(34 citation statements)

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“…The common element in these patients is stress-induced activation of the sympathetic system, leading to an excess catecholamine release. The direct cardiotoxic effects of catecholamines are a well-recognized phenomenon [2,3,4,5]. Animal models have shown that catecholamines can induce myocardial stunning [6, 7] and PET studies have shown metabolic evidence of myocardial stunning in cases of takotsubo cardiomyopathy [8].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Stress-Induced (Takotsubo) Cardiomyopathy

Cherian

Angelis²,

Filiberti³

et al. 2006

Cardiology

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Takotsubo cardiomyopathy is a recently recognized form of transient left ventricular dysfunction that is presumably precipitated by stress and may clinically resemble an acute coronary syndrome. These patients have an akinetic left ventricular apex in an unusual shape that resembles a takotsubo. Although reports of single episodes of takotsubo cardiomyopathy are not infrequent in recent medical literature, we report a case of recurrence that may provide more insight into the nature of this syndrome.

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Section: Discussionmentioning

confidence: 99%

Recurrence of Stress-Induced (Takotsubo) Cardiomyopathy

Cherian

Angelis²,

Filiberti³

et al. 2006

Cardiology

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Section: Malignant Pheochromocytomamentioning

confidence: 99%

“…A combination of cyclophosphamide, vincristine and dacarbazine showed a 57% complete or partial tumor response, while 79% had either a complete or partial biochemical response (Averbuch et al, 1988). Patients with large tumor burdens may present with massive release of catecholamines -"catecholamine storm" -within the first few hours after administration of the first course of chemotherapy (Quezado et al, 1992).External beam radiation is used for palliation of chronic pain and symptoms of local compression arising from these tumors (Siddiqui et al, 1988). However, no systemic effects on tumor burden or hormone levels were observed.…”

mentioning

confidence: 99%

Pheochromocytoma and Paraganglioma

Pacák

Wimalawansa

2015

Endocrine Practice

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“…In most reported cases, post-resection resolution of cardiomyopathy takes several months to occur (1, 2, 10, 18 -20). However, medical therapy with an a-blocker, angiotensin converting enzyme (ACE) inhibitor, and/or b-blocker has been reported to reverse the condition in 3-14 days (3,6,11,13,21). Our patient's left ventricular function improved from 10% to 60% in 5 days.…”

Section: Discussionmentioning

confidence: 73%

Multiple endocrine neoplasia 2A syndrome presenting as peripartum cardiomyopathy due to catecholamine excess

Kim

Reutrakul²,

Davis³

et al. 2004

European Journal of Endocrinology

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We report the case of a 24-year-old female with a history of medullary thyroid carcinoma who presented at 38 weeks gestation with acute chest pain and shortness of breath. She was found to be in pulmonary edema and respiratory failure. An emergency cesarean section was performed. Subsequently, an echocardiogram revealed an ejection fraction of 10%. After medical therapy with digoxin, milrinone, captopril and diuretics, her condition improved rapidly and a repeat echocardiogram showed that the left ventricular function had normalized. Diagnosis of pheochromocytoma was made by urine and plasma catecholamine measurements. Magnetic resonance imaging revealed a 3.7 cm left adrenal mass. Increased uptake activity was seen in the same region by an 131 I-metaiodobenzylguanidine (MIBG) scan. The patient underwent successful surgical resection of the pheochromocytoma. Subsequent DNA analysis revealed that the patient had a mutation of the RET proto-oncogene. The same mutation was also found in several of her family members. In summary, we report a case of multiple endocrine neoplasia 2A presenting as peripartum cardiomyopathy and cardiovascular collapse. Pheochromocytoma should be considered as a potential cause of peripartum cardiomyopathy.European Journal of Endocrinology 151 771-777

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Reversible myocardial depression after massive catecholamine release from a pheochromocytoma

Cited by 56 publications

References 0 publications

Recurrence of Stress-Induced (Takotsubo) Cardiomyopathy

Recurrence of Stress-Induced (Takotsubo) Cardiomyopathy

Pheochromocytoma and Paraganglioma

Multiple endocrine neoplasia 2A syndrome presenting as peripartum cardiomyopathy due to catecholamine excess

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