Reversible night blindness in a patient with neuroendocrine tumour of pancreas

S, Appaswamy; Silva, D De; Tyagi, AK; Grocott, Lesley; Heath, P D; Gillow, Timothy

doi:10.1038/sj.eye.6701619

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Vitamin A deficiency has been previously documented in patients suffering from chronic pancreatic insufficiency (alcoholic pancreatitis, cystic fibrosis) and in intestinal bypass surgery 2 4–6. These studies have had success with both oral and intramuscular treatment of vitamin A.…”

Section: Discussionmentioning

confidence: 99%

Nyctalopia: the sequelae of hypovitaminosis A

Tiang

Warne²

2010

Case Reports

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SummaryWe present a case of night blindness due to vitamin A deficiency in a gentleman who had previously undergone a pancreaticoduodenostomy 10 years ago. The deficiency was attributed self-cessation of his pancreatic supplements without being aware of the possible consequences.The diagnosis and management of this patient is presented here, along with a discussion of similar cases in the literature. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Nyctalopia: the sequelae of hypovitaminosis A

Tiang

Warne²

2010

Case Reports

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“…The best‐documented symptom of vitamin A deficiency in this population is night blindness, or prolonged dark adaptation. One patient in a case report complained of inability to see in dimly lit areas but adequate vision in good lighting 47 . A case report of a patient 10 years post–total pancreatectomy who developed night blindness and dry skin was found to have serum vitamin A deficiency, among other nutrient deficiencies, related to his self‐withdrawal from PERT 48 .…”

Section: Fat‐soluble Vitaminsmentioning

confidence: 99%

“…One patient in a case report complained of inability to see in dimly lit areas but adequate vision in good lighting. 47 A case report of a patient 10 years post-total pancreatectomy who developed night blindness and dry skin was found to have serum vitamin A deficiency, among other nutrient deficiencies, related to his self-withdrawal from PERT. 48 Deficiency may be unknown by the patient; of 7 patients with pancreatic insufficiency with low serum retinol, only 3 had night blindness, and none showed other physical signs or symptoms of deficiency, such as xerosis, hyperkeratinized skin lesions, bone pain, or anemia.…”

Section: Vitamin Amentioning

confidence: 99%

Nutrition Implications for Long‐Term Survivors of Pancreatic Cancer Surgery

Petzel

Hoffman

2017

Nut in Clin Prac

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With slowly increasing survival rates in pancreatic cancer and international consensus guidelines recommending surgical resection of premalignant lesions, survival post-pancreatic resection is increasing. With longer survival time, the significant comorbidities of such major surgery have far-reaching effects on the nutrition status of the survivor of pancreatic cancer. This review describes the many nutrition-related side effects of pancreatic surgery, including the development of pancreatic enzyme insufficiency, micronutrient deficiencies, diabetes, fatty liver, and metabolic bone disease. Beyond causing additional medical problems, each of these can have significant effects on quality of life and functional status. The potential mechanisms, diagnosis criteria, and potential treatments of these conditions are described. Overall, little literature exists to fully describe the effects of these comorbidities, and even less is able to guide effective treatments for this population. Clinicians caring for these patients should begin incorporating goals for promotion of long-term health and reduction of these known and reported comorbidities in patients who have undergone pancreatic surgery. Treatment plans in this population remain understudied, and clinicians may need to consider recommendations for similar disease states when developing interventions for these patients.

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“…Исследователи не всегда проводили параллель между дефицитом витаминов и ЭНПЖ после резекции ПЖ. В ранних исследованиях сообщалось, что у пациентов редко развиваются клинические симптомы дефицита витамина А [29,30], что могло быть связано с короткой продолжительностью жизни после резекции ПЖ. В сообщении Sharma и соавт.…”

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Nutritional status of patients undergoing pancreatic resection

Malykh

Дубцова

Винокурова

et al. 2022

jour

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Changes in the exocrine function of the pancreas often develops after proximal and distal resections. Exocrine pancreatic insuﬃciency (EPI) is characterized by a reduced secretion of pancreatic enzymes, because of which the digestion and absorption of nutrients is impaired. Clinical manifestations of EPI and, as a consequence, changes in nutritional status signiﬁcantly aﬀect the quality of life of patients.

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Reversible night blindness in a patient with neuroendocrine tumour of pancreas

Cited by 4 publications

References 7 publications

Nyctalopia: the sequelae of hypovitaminosis A

Nyctalopia: the sequelae of hypovitaminosis A

Nutrition Implications for Long‐Term Survivors of Pancreatic Cancer Surgery

Nutritional status of patients undergoing pancreatic resection

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