Reversible ophthalmoplegia in CPEO

Abstract

Purpose: To present a case of improvement of ocular motility in a patient with chronic progressive external ophthalmoplegia (CPEO) with Coenzyme Qio Methods: Coenzyme QIO 300 mg daily was given for three years with a three-day trial period of 200 mg daily after one year. Ocular ductions were measured by synoptophore. Results: Ocular ductions improved with treatment with Coenzyme QiaConclusion: Coenzyme Qw, is effective in limiting the severity of ophthalmoplegia in this case.

Coenzyme Q10 vitreous levels after administration of coenzyme Q10 eyedrops in patients undergoing vitrectomy

“…CoQ 10 is also a redox component of electron transport chains in extramitochondrial membranes, where it acts as a powerful antioxidant and membrane stabilizer. Indirect evidence also points out that CoQ 10 may be a useful therapeutic agent in ocular diseases where oxidative stress and apoptotic cell death are important pathogenic factors (Dunlop & Dunlop 1995; Blasi et al. 2001).…”

“…CoQ 10 is also a redox component of electron transport chains in extramitochondrial membranes, where it acts as a powerful antioxidant and membrane stabilizer. Indirect evidence also points out that CoQ 10 may be a useful therapeutic agent in ocular diseases where oxidative stress and apoptotic cell death are important pathogenic factors (Dunlop & Dunlop 1995;Blasi et al 2001). The purpose of this study was to assess the intraocular penetration of CoQ 10 by determining its vitreous concentration in patients treated with a commercially available topical eye preparation (Coqun Ò eyedrops; Visufarma SpA, Rome, Italy) and in untreated patients.…”

The Universality of Bioenergetic Disease: Age‐associated Cellular Bioenergetic Degradation and Amelioration Therapy

“…Since this pioneering work, there have been many studies using coenzyme Q 10 as the therapeutic compound, and this work has reinforced the effectiveness of redox therapy for many patients with mitochondrial disease (bioenergy capacity defects) 35‐38 as well as other disease states. 39‐44 Coenzyme Q plays a central role in the respiratory chain, acting as electron acceptor for both complexes I and II and the electron donor to complex III. It is the only element of the chain whose external addition to the cell is possible.…”