Reversible Plasma and Red Blood Cells Volumes Increases in Acromegaly

Strauch, G; A, Lego; Therain, F.; Bricaire, H

doi:10.1530/acta.0.0850465

Cited by 47 publications

(22 citation statements)

References 10 publications

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“…In addition, the increase in extracellular fluid was reduced after treatment of the disease [9]. Our study showed that the serum Na concentration was higher in HT than in NT, and significantly correlated with blood pressure.…”

Section: Discussionmentioning

confidence: 49%

“…Many investigators have reported that an increase in extracellular fluid and retention of Na exist in acromegaly [7][8][9][10][11][12][13][14][15], and these were thought to contribute to hypertension. In addition, the increase in extracellular fluid was reduced after treatment of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

“…Quite interestingly, a high incidence of hypertension has been noticed in patients with acromegaly [2][3][4][5][6]. It has been reported that plasma volume and serum Na are increased in acromegaly [7][8][9][10][11][12][13][14][15], and these are able to induce hypertension.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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Abstract.Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension.The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium (Na) concentration.In addition, IGF-I and Na were significantly different in hypertensive and normotensive groups. Seventy-five percent of hypertensive patients had a family history of hypertension.IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it. In patients with a family history of hypertension, blood pressure was positively correlated with IGF-I and serum Na, but IGF-I was not correlated with serum Na. In patients without such a family history, blood pressure had a good correlation only with age, and IGF-I was not significantly correlated with blood pressure. In addition, the incidence of hypertension in this group was the same as or lower than that in the general population.The above results suggest that the genetic factor produces hypertension in acromegaly by two ways, by increasing Na and enhancing IGF-I production by GH.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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“…For subjects at rest, many studies have demonstrated the sodium-and water-retaining effects of GH (1±3). Body-¯uid volume decreases in GHde®cient patients (3), but increases in acromegalic patients, who secrete excess GH (1,4). In both groups of patients, body¯uid is normalized after, respectively, GH treatment and surgical treatment of the hypophysis.…”

Section: Introductionmentioning

confidence: 99%

Effect of hydration on exercise-induced growth hormone response

Peyreigne¹,

Bouix²,

Fédou³

et al. 2001

European Journal of Endocrinology

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Design: Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating. Thus, the aim of this study was to investigate the effect of¯uid intake on the exercise-induced GH response. Methods: Seven healthy male volunteers (age: 27X4^1X3 years, weight: 74X5^1X1 kgY height: 179X32X3 cm performed a 40-min submaximal rectangular cycling exercise in two different sessions. The ®rst session (Session 1) was performed without water intake, and the second (Session 2) involved the ingestion of spring water (four intakes) corresponding to the volume of water lost during the ®rst session. Results: In session 1, the water loss was 568^32 mlX In Session 2, the volume of water loss was not signi®cantly different from the volume of¯uid intake 524^16 versus 568^32 ml respectively). The decrease in plasma volume was signi®cantly reduced in Session 2 26X69^1X59% versus 211X31 X89%; P , 0X05X In Session 1, the GH concentration was signi®cantly lower than that during Session 2 after 25 min 3X04^1X05 versus 5X26^1X81; P , 0X05 and after 40 min 13X7^3X55 versus 17X60^4X14 ngaml; P , 0X05 of exercise. The total GH response was signi®cantly lower in Session 1 than in Session 2 136X6^39X2 versus 202X4^58X9 ngamlXmin; P , 0X05X Conclusions: We conclude that the exercise-induced GH response decreases when exercise is performed without¯uid intake.

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“…Slow postoperative necrotic or apoptotic process which resulted in the late normalization of nadir GH and gradual declination of IGF-1 described here may occur. The process may be attributed to the following possible mechanisms including 1) ongoing reduction of the blood supply induced by surgical manipulation, 2) reduction of blood volume accompanied with acute decrease of GH levels [14], 3) decrease of angiogenic effect of IGF-1 [15], 4) apoptosis of residual neoplastic cells induced by cutoff of the anti-apoptotic and cellular proliferative effects of GH and IGF-1 [15][16][17].…”

Section: Resultsmentioning

confidence: 99%

Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomas

et al. 2011

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InsulIn-lIke growth factor-1 (IGF-1), primarily produced in the liver under the control of growth hormone (GH) [1][2][3][4], mediates most of the major activities of GH [1,2]. Because blood IGF-1 reveals overall GH secretion during the period of prior 24 hrs and minimally fluctuates over this period [5][6][7], its concentration has been a reliable indicator of GH secretion [1,3,8]. Thus, the recent criteria for surgical cure of acromegaly mandate normalization of IGF-1. In the previous report, we showed that the decrease in IGF-1 was slower in operated acromegalic patients than would be expected from the half-life of the carrier protein-bound peptide [9]. And we suggested that this slow decline allows us to postpone decisions regarding the patients' postoperative status and the administration abstract. To know the longitudinal shift of blood IGF-1 of cured acromegaly, we conducted retrospective survey of changes in blood IGF-1 over two years, which has not been previously investigated. Blood IGF-1 levels were measured for longer than 2 years after TSS in 37 patients whose nadir GH during postoperative oral glucose tolerance test (OGTt) was under 1 ng/mL. Blood IGF-1 very gradually declined after three months; 230.6 (mean) ng/mL at 3-12 months, 202.3 ng/mL at 12-24 months, and 198.6 ng/mL at 24-36 months. Their SD values, calculated based on standard IGF-1 values of age-and sex-matched Japanese population, also slowly decreased after three months; 1.69 (mean) at 3-12 months, 1.23 at 12-24 months, and 1.12 at 24-36 months. Very slow decrease of the IGF-1 levels continued beyond the first several months and even the first year after TSS. The declination of values is greater than that associated with aging. This declination may be at least partially a reflection of the slow decrease and late normalization of GH secretion.Key words: Acromegaly, Insulin-like growth factor-1 (IGF-1), Growth hormone, Declination, Transsphenoidal surgery of additional therapy for at least one month after surgery. Since then, we have been monitoring the IGF-1 fluctuations in postoperative acromegalic patients and have observed that IGF-1 very gradually decreased over a year in some patients. In order to know the longitudinal shift of the IGF-1, if any, we retrospectively assessed the blood IGF-1 levels serially for more than two years in postoperative acromegalics. Materials and Methods Subjects and methodPatients were 37, 12 males and 25 females, acromegalics who underwent transsphenoidal surgery since 2001 to 2008, whose nadir GH during postoperative OGTt was under 1 ng/mL, and in whom IGF-1 levels were serially measured over two years. The patients' ages ranged from 20 to 76 years (53.5±11.7, mean±SD). The mean preoperative IGF-1 level was 895.0 ± 360.1 (SD) ng/mL. The IGF-1 levels were measured during 1-4 weeks, 1-3 months, 3-12 months, 12-24 months,

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Reversible Plasma and Red Blood Cells Volumes Increases in Acromegaly

Cited by 47 publications

References 10 publications

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Effect of hydration on exercise-induced growth hormone response

Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomas

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