Reversible pure word deafness due to inferior colliculi compression by a pineal germinoma in a young adult

Joswig, Holger; Schönenberger, Ursula; Brügge, Detlef; Richter, Heiko; Surbeck, Werner

doi:10.1016/j.clineuro.2015.08.034

Cited by 15 publications

(7 citation statements)

References 6 publications

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“…Brainstem nuclei such as the inferior colliculus (IC), superior colliculus (SC) and the superior olivary complex (SOC), as well as thalamic nuclei such as the medial geniculate nucleus (MG) and lateral geniculate nucleus (LG) modulate auditory/auditory-motor (IC, SOC and MG) and visual/oculo-motor (SC and LG) functions. These nuclei are also involved in the pathogenesis of disorders such as auditory agnosia, pure-word deafness, eye-movement and visual-field deficits, hallucinations in Parkinson’s disease, and glaucoma (Joswig et al, 2015; Pasu et al, 2015; Wang et al, 2015; Biotti et al, 2016; Lee et al, 2016). Nevertheless, a stereotaxic probabilistic structural atlas of these nuclei in living humans does not exist.…”

Section: Introductionmentioning

confidence: 99%

In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 Tesla MRI

et al. 2019

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Despite extensive neuroimaging research of primary sensory cortices involved in auditory and visual functions, subcortical structures within these domains, such as the inferior and superior colliculi, the medial and lateral geniculate nuclei and the superior olivary complex, are currently understudied with magnetic resonance imaging (MRI) in living humans. This is because a precise localization of these nuclei is hampered by the limited contrast and sensitivity of conventional neuroimaging methods for deep brain nuclei. In this work, we used 7 Tesla multi-modal (T 2 -weighted and diffusion fractional anisotropy) 1.1 mm isotropic resolution MRI to achieve high sensitivity and contrast for single-subject brainstem and thalamic nuclei delineation. After precise coregistration to stereotactic space, we generated an in vivo human probabilistic atlas of auditory (medial geniculate nucleus, inferior colliculus, and superior olivary complex) and visual (lateral geniculate nucleus and superior colliculus) subcortical nuclei. We foresee the use of this atlas as a tool to precisely identify the location and shape of auditory/visual deep nuclei in research as well as clinical human studies.

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Section: Introductionmentioning

confidence: 99%

In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 Tesla MRI

et al. 2019

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“…Individual cases of pineal region tumors presenting with hearing impairment are summarized in Table 1 [1,3,5,7,[9][10][11][12][13][14][15][16][17][18][19]. Seventeen similar cases were collected, all of which had bilateral hearing impairment.…”

Section: Literature Reviewmentioning

confidence: 99%

An Unusual Presentation of Hearing Impairment in an Adult with Pineal Region Germinoma: A Case Report

Mahboob,

Hamzah,

Alothman

et al. 2023

Case Rep Oncol

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Tumors of the pineal region typically present with symptoms and signs of mass effect and increased intracranial pressure. However, although rare and can be overlooked, hearing impairment is a potential clinical finding in these cases. The authors describe a 24-year-old male who presented to the emergency room complaining of bilateral hearing impairment. Brain computed tomography showed a pineal region tumor. Histopathological examination demonstrated features consistent with germinoma. This case reports a rare presentation rarely seen in the literature and in practice as evident by the conducted literature review. Therefore, we highlight the importance of considering hearing impairment as a presenting symptom of pineal region tumors since prompt recognition and intervention, as demonstrated in this case, can lead to successful outcomes.

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“…Furthermore, the majority of word-deafness reported cases are due to lesions of the superior left temporal lobe including primary auditory area (Brodmann Areas 41 and 42; e.g., Auerbach et al, 1982; Gutschalk et al, 2015; Stefanatos, Gershkoff, and Madigan (2005)), suggesting a purely perceptual deficit, and hence, an auditory (verbal) agnosia. However, some additional localizations of the pathology associated with this syndrome have been reported; Joswig, Schönenberger, Brügge, Richter, and Surbeck (2015) reported a case of pure word deafness, associated with a pineal germinoma on the inferior colliculi in a young patient. After percutaneous radiation therapy, the size of the tumor decreased significantly, but the audiometry demonstrated a complete regression of the auditory deficit.…”

Section: Pure Word-deafnessmentioning

confidence: 99%

Some rare neuropsychological syndromes: Central achromatopsia, Bálint’s syndrome, pure word-deafness, supplementary motor area aphasia.

Ardila

2017

Psychology & Neuroscience

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There are some unusual neuropsychological syndromes rarely reported in neuropsychological literature. This article presents a review of four of these unusual clinical syndromes: (a) Central achromatopsia (loss in the perception of colors due to a lesion of the visual association cortex); (b) Bálint's syndrome (simultanagnosia, optic ataxia and gaze apraxia associated with bilateral parietal-occipital pathology); (c) pure worddeafness (clinical syndrome characterized by an inability to understand spoken language with preserved speech production and reading ability); and (d) aphasia of the supplementary motor area (significant difficulty in initiating and maintaining speech, regardless if the patient makes significant effort to speak due to a damage in the left supplementary motor area). It is concluded that although these syndromes are rare, it is fundamental to consider them to understand the brain organization of cognition. Their understanding is also crucial in the clinical analysis of patients with brain pathologies.

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Reversible pure word deafness due to inferior colliculi compression by a pineal germinoma in a young adult

Cited by 15 publications

References 6 publications

In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 Tesla MRI

In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 Tesla MRI

An Unusual Presentation of Hearing Impairment in an Adult with Pineal Region Germinoma: A Case Report

Some rare neuropsychological syndromes: Central achromatopsia, Bálint’s syndrome, pure word-deafness, supplementary motor area aphasia.

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