Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy

Abstract

We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis. After discontinuation of the treatment, gradual decline of bone mineral density at lumbar and femoral sites was detected with serial DEXA measurements. To the best of our knowledge, although various abnormalities of bone due to retinoids have been described before, reversible sclerotic changes have not been reported.

The case of development of bone toxicity, simulating a relapse of the underlying disease, in a child with neuroblastoma on the background of therapy with 13-cis-Retinoic acid

“…В литературе описаны и более редкие осложнения в виде поражения костной ткани с формированием остеофитов и локального отека костного мозга [11,13]. Гиперостозы и энтезопатии являются наиболее распространенными костными поражениями [11,14].…”