Reversible Sequestration of Nitric Oxide by Hemoglobin During Hemodialysis in End-Stage Renal Disease

Kang, Ellen S.; Cates, Taylor; Miles, Don E.; Tevlin, Marjorie T.; Acchiardo, Sergio R.

doi:10.1097/00000441-200102000-00002

Cited by 7 publications

(1 citation statement)

References 34 publications

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“…In the literature, the results of the studies that investigated the plasma levels and effects of NOx in patients with CKD were controversial. Some studies have supported that plasma NOx levels were lower in CKD patients (23,(26)(27). Total NO production was in a small number of patients with chronic renal failure, but the patient group was reported to be hypertensive during the investigation (28).…”

Section: Discussionmentioning

confidence: 98%

Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Buyan¹,

Akçaboy²,

Goktas³

et al. 2017

Turk J Med Sci

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IntroductionWhole blood viscosity (WBV) is increasingly recognized as a factor implicated in the genesis of atherosclerosis and the progression of vascular disease, such as chronic kidney disease (CKD), in high-risk patients. The principal determinants of WBV are hematocrit, red blood cell deformability, and the viscosity of plasma. Changes in whole blood viscoelasticity are associated with cardiovascular and cerebrovascular complications among patients with CKD, especially in the fifth stage (1-3). Mechanical interaction between blood and vessels mediated by WBV has a crucial role in the release of endothelium-derived mediators such as NOx and endothelin, and subsequent vascular remodeling (1,4).The aim of the study was to investigate the effects of WBV and plasma NOx values on cerebral and cardiovascular risks associated with CKD and to compare the impact of hemodialysis (HD) and peritoneal dialysis (PD) treatments on WBV and plasma NOx levels in patients with CKD. Materials and methodsA cross-sectional study was performed in patients who were admitted to our pediatric nephrology department. The study fulfilled the requirements of good clinical practice according to the Declaration of Helsinki, and was approved by our local ethics committee (Date: 13.04.2011, Number: 66). Patients and their families were informed, and all subjects gave written informed consent prior to enrollment.Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods:The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined.Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly low viscosity levels. Plasma nitric oxide levels were higher in all patient groups than those in the controls. No statistically significant difference was present in middle cerebral artery blood flow velocity between the patient and control groups. Even when systolic functions were normal, the patient group had significant deterioration in diastolic functions, suggesting morbidity and mortality risks. Conclusions:Cerebral blood flow velocities were not affected by viscosity and nitric oxide levels, suggesting that cerebral circulation has the ability to make adaptive modulation. The metabolism of nitric oxide levels needs further investigation and studies in patients with chronic renal disease.

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Section: Discussionmentioning

confidence: 98%

Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Buyan¹,

Akçaboy²,

Goktas³

et al. 2017

Turk J Med Sci

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Effect of hemoglobin on the NO-donor ability of μ2-S-bis(pyrimidine-2-thiolato)tetranitrosyldiiron

et al. 2010

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The hydrolysis of the iron nitrosyl complex [Fe 2 (μ 2 SC 4 H 3 N 2 ) 2 (NO) 4 ] (C 4 H 3 N 2 S -is pyri midine 2 thiolate) in the presence of hemoglobin (Hb) is accompanied by the NO release into a solution. In the absence of Hb, the starting complex is oxidized by nitric oxide that is released into a solution, which leads to further transformations of NO, nitric oxide being present in the solution only partially. The effective rate constant for the decomposition of the complex is high and depends on its concentration. On the one hand, in the presence of Hb, NO molecules rapidly and irreversibly bind to Hb to form HbNO, which is the intermediate in the nitric oxide metabolism. On the other hand, the reversible binding of the iron nitrosyl complex to the surface functional groups of Hb leads to a decrease in its concentration in a solution and deceleration of the formation of NO. Therefore, Hb can ensure the complete and more pro longed assimilation of NO.The iron thiolate nitrosyl complexes [Fe 2 (SR) 2 (NO) 4 ], like S nitrosothiolates 1 and diazeniumdiolates, 2,3 are hydrolyzed in protic media to form nitric oxide 4 and be long to a new class of NO donors holding promise for the pharmacology. 5-10 Previously, we have found that iron sulfur nitrosyl complexes are decomposed with the NO release in protic media without additional activation, 4,11 the rate constants for this reaction being dependent on the molecular structures of the complexes. In the present study, we investigated the new dinuclear iron tetranitrosyl complex with the pyrimidine 2 thiolate ligand [Fe 2 (μ 2 SC 4 H 3 N 2 ) 2 (NO) 4 ] (1) exhibiting high antitumor activity (86-88% of the growth retardation in human tumor cells, the ovarian cancer cell line SCOV3). 7 The pyrimidine 2 thiolate ligand C 4 H 3 N 2 S -can be considered as the struc tural analog of antimetabolites (6 mercaptopurine, etc.), which are used for the synthesis of antitumor agents, 12-17 and NO is a key agent in the cancer genesis. 18 The direct determination of the NO concentration in a solution by the electrochemical method with the use of a sensor electrode showed that the maximum NO concen tration after the hydrolysis of complex 1 in a protic medi um is substantially lower than the stoichiometrically pos sible yield, the decomposition of complex 1 occurring rap idly. 19 By contrast, a larger amount of NO is released in the presence of hemoglobin (Hb) (one NO molecule per molecule of the complex), and the decomposition occurs more slowly. In our opinion, this fact is important both in terms of the insight into the mechanisms of reactions of heme proteins with new exogenic NO donors and from the point of view of drug design. Thus, the pharmacologically active agent (NO donor) should have the period of perfor mance sufficient for the NO delivery to target sites.The formation of Hb(NO) 4 in the reaction with Hb can serve as a convenient method for the estimation of the NO donor ability of iron nitrosyl complexes. 4 Due to the high rate constant for the reaction of Hb with NO (k...

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The effect of pulse pressure variation compared with central venous pressure on intraoperative fluid management during kidney transplant surgery: a randomized controlled trial

Kannan

Loganathan

Kajal

et al. 2021

Can J Anesth/J Can Anesth

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Reversible Sequestration of Nitric Oxide by Hemoglobin During Hemodialysis in End-Stage Renal Disease

Cited by 7 publications

References 34 publications

Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Effect of hemoglobin on the NO-donor ability of μ2-S-bis(pyrimidine-2-thiolato)tetranitrosyldiiron

The effect of pulse pressure variation compared with central venous pressure on intraoperative fluid management during kidney transplant surgery: a randomized controlled trial

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