Reversible splenial lesion syndrome (RESLES) coinciding with cerebral venous thrombosis: a report of two cases

Abstract

A total of two postpartum women with no noteworthy medical history presented with persistent headache. Brain magnetic resonance imaging (MRI) of both revealed extensive cerebral venous thrombosis, concurrently with abnormal signals of the splenium of the corpus callosum (SCC): The splenium appeared hyperintense on T2-weighted sequences, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI) imaging, and hypointense on T1 sequences and apparent diffusion coefficient (ADC) map. The patients were given thrombolytic therapy. Clinically, both patients achieved recovery with no neurologic sequelae, and follow-up MRI revealed complete resolution of the lesion in the SCC at day 36 and day 37 after initial presentation, respectively.

A rare case of reversible splenial lesion in third trimester

“…They arise from the medial aspect of the corpus callosum. These lesions tend to disappear overtime [3] .…”

Encefalopatia/Encefalite Ligeira com Lesão Reversível do Corpo Caloso: Entidade Benigna Rara com Diagnósticos Diferenciais Menos Benignos

“…Entre os vários precipitantes descritos na literatura, destaca--se a patologia infeciosa, particularmente vírica, embora possa haver associação com infeções bacterianas. 3,10 A patogénese da MERS não está bem definida, principalmente pela natureza heterogénea das condições subjacentes, 12 formulando-se hipóteses como presença de edema intramielínico, dano axonal, edema citotóxico ou stress oxidativo. Há patologias neurológicas com restrição à difusão na substância branca, provavelmente decorrentes de edema intramielínico separando as camadas de mielina, igualmente reversíveis.…”

Anti-glial fibrillary acidic protein antibodies as a cause of reversible splenial lesion syndrome (RESLES): a case report

“…RESLES most commonly occurs in patients with seizures, particularly following antiepileptic drugs withdrawal. RESLES can also cause by infections, highaltitude cerebral edema, hypoglycemia, hyper/hyponatremia, cerebral venous thrombosis, several non-epileptic pharmacological agents, and miscellaneous conditions including anorexia nervosa, malnutrition, vitamin B12 deficiency, Charco-Marie-Tooth disease, systemic lupus erythematosus, and eclampsia [1][2][3]. Autoimmune encephalitis as a rare condition associated with RESLES was reported in only one anti-NMDAR encephalitis, one anti-VGKC encephalitis, and one anti-Yo encephalitis case, respectively [3][4][5].…”