Reversible Switching of the Interparticle Distance in DNA-Templated Gold Nanoparticle Dimers

Lermusiaux, Laurent; Середа, А. П.; Portier, Benjamin; Larquet, Éric; Bidault, Sébastien

doi:10.1021/nn304599d

Cited by 68 publications

(82 citation statements)

References 46 publications

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“…106,118 Bidault et al reported reversible switching of inter-particle distances in DNA bridged gold nanoparticle dimers. 119 The distance between gold nanoparticles could be switched from 5 nm to 15 nm, by hybridizing or removing a single DNA strand. A recent report revealed that a 1 nm gap can be generated by DNA-tailored nanoparticles.…”

Section: Electromigration Break Junctions (Ebjs)mentioning

confidence: 99%

Single-molecule electronics: from chemical design to functional devices

et al. 2014

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The use of single molecules in electronics represents the next limit of miniaturisation of electronic devices, which would enable us to continue the trend of aggressive downscaling of silicon-based electronic devices. More significantly, the fabrication, understanding and control of fully functional circuits at the single-molecule level could also open up the possibility of using molecules as devices with novel, not-foreseen functionalities beyond complementary metal-oxide semiconductor technology (CMOS). This review aims at highlighting the chemical design and synthesis of single molecule devices as well as their electrical and structural characterization, including a historical overview and the developments during the last 5 years. We discuss experimental techniques for fabrication of single-molecule junctions, the potential application of single-molecule junctions as molecular switches, and general physical phenomena in single-molecule electronic devices.

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Section: Electromigration Break Junctions (Ebjs)mentioning

confidence: 99%

Single-molecule electronics: from chemical design to functional devices

et al. 2014

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“…DNA‐based templating approaches allow AuNPs to be precisely positioned in an assembly by Watson–Crick base pairing to provide a tunable interparticle gap . The interparticle distance can be changed by using various chemical reactions of DNA linkers, including cleavage and strand exchange . Despite such steady progress, however, it still remains a challenging task to tune the interparticle distance in single AuNP oligomers in a rapid and reversible way.…”

Section: Introductionmentioning

confidence: 99%

Reversible Shrinkage of DNA‐Functionalized Gold Nanoparticle Assemblies Revealed by Surface Plasmon Resonance

Wang

Akiyama

et al. 2018

Biotechnology Journal

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A technique for tuning interparticle distance in plasmonic gold nanoparticle (AuNP) assemblies has shown great potential for the development of optoelectronic nanodevices. However, it still remains a challenge to reversibly alter the distance in a facile manner. DNA-templated AuNP assemblies are among the mostly investigated plasmonic nanomaterials. In previous work, salt-induced structural shrinkage of DNA-templated AuNP (5 nm in diameter) dimers/trimers is demonstrated only by electron microscopic analyses. In the present study, interparticle distance is modulated in larger AuNP (15 nm or 20 nm in diameter) dimers that exhibit strong surface plasmon resonance (SPR). The reversible SPR shift is achieved by using the temperature-dependent shrinkage/extension of the DNA-templated AuNP dimers. The present proof-of-concept study suggests a potential application of the reversible structural change to optical switching.

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“…One group acknowledged the possibility of drying effects changing the nanostructure of the sample, but there was no investigation on the magnitude of these effects (Elbaz et al, 2013). Cryo-TEM has been applied to these samples for imaging the nanostructure in a hydrated state, though this research did not consider the assembly distortions that can arise during the vitrification process in these samples (Lermusiaux et al, 2012). To image these assemblies in their native state, we utilized a specialized specimen holder that allows a solution to be introduced and sealed between two thin film silica nitride (SiN) membrane windows, maintaining hydration while under vacuum within the microscope column (de Jonge et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Drying Effect Creates False Assemblies in DNA-Coated Gold Nanoparticles as Determined Through In Situ Liquid Cell STEM

et al. 2014

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The drying effect associated with utilizing transmission electron microscopy to study deoxyribonucleic acid (DNA)-coated gold nanoparticles (AuNPs) remains largely uninvestigated, though this technique is frequently utilized to characterize nanoparticle-DNA interactions. Investigation of the drying effect is essential to the progress of the many fields that utilize AuNPs, including cancer research. In this study, we compare DNA hybridization-directed nanoparticle assemblies with control samples omitting the necessary complementary DNA, effectively blocking directed assembly, in both the liquid state and the dry state, within a scanning transmission electron microscope. We show that the dry samples contain AuNPs spaced at significantly smaller intervals than identical samples measured in situ, with no dependence on the DNA bound to the AuNPs in the dry samples. A partially wet sample, with distances measured along the drying edge, provided an intermediate binding distance, strengthening the conclusion that drastic differences observed between the dry and in situ samples are due to a pronounced drying effect. This drying effect will falsely indicate certain grouping arrangements and will change the impression of the size of the groups formed, providing misinformation for the development of these controlled assemblies that could impact applications such as targeted drug vehicles for cancer treatment.

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Reversible Switching of the Interparticle Distance in DNA-Templated Gold Nanoparticle Dimers

Cited by 68 publications

References 46 publications

Single-molecule electronics: from chemical design to functional devices

Single-molecule electronics: from chemical design to functional devices

Reversible Shrinkage of DNA‐Functionalized Gold Nanoparticle Assemblies Revealed by Surface Plasmon Resonance

Drying Effect Creates False Assemblies in DNA-Coated Gold Nanoparticles as Determined Through In Situ Liquid Cell STEM

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