Reversible tissue sticker inspired by chemistry in plant-pathogen relationship

Lee, Jeehee; Park, Eunsook; Lee, Kyueui; Shin, Mikyung; Lee, Soo Hyun; Moreno-Villaécija, Miguel Ángel; Lee, Haeshin

doi:10.1016/j.actbio.2022.09.075

Acta Biomaterialia

2023

DOI: 10.1016/j.actbio.2022.09.075

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Reversible tissue sticker inspired by chemistry in plant-pathogen relationship

Jeehee Lee

Eunsook Park

Kyueui Lee

et al.

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2024

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Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Han,

Nam,

Chung

et al. 2024

Nano Lett.

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The advancement of effective nasal mucoadhesive delivery faces challenges due to rapid mucociliary clearance (MCC). Conventional studies have employed mucoadhesive materials, mainly forming spherical nanoparticles, but these offer limited adhesion to the nasal mucosa. This study hypothesizes that a 2D nanoscale structure utilizing adhesive polyphenols can provide a superior strategy for countering MCC, aligning with the planar mucosal layers. We explore the use of tannic acid (TA), a polyphenolic molecule known for its adhesive properties and ability to form complexes with biomolecules. Our study introduces an unprecedented 2D nanopatch, assembled through the interaction of TA with green fluorescent protein (GFP), and cell-penetrating peptide (CPP). This 2D nanopatch demonstrates robust adhesion to nasal mucosa and significantly enhances immunoglobulin A secretions, suggesting its potential for enhancing nasal vaccine delivery. The promise of a polyphenol-enabled adhesive 2D nanopatch signifies a pivotal shift from conventional spherical nanoparticles, opening new pathways for delivery strategies through respiratory mucoadhesion.

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Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Han,

Nam,

Chung

et al. 2024

Nano Lett.

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show abstract

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Reversible tissue sticker inspired by chemistry in plant-pathogen relationship

Cited by 1 publication

References 56 publications

Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

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