Reversible Ventricular Dysfunction Takotsubo (ampulla-shaped) Cardiomyopathy

Akashi, Yoshihiro J.

doi:10.2169/internalmedicine.44.175

Cited by 41 publications

(59 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three different studies reported increased plasma epinephrine and/or norepinephrine levels in this category of patients 10,19,20 as in the present study, whereas Madhavan et al observed no elevation of catecholamines. 21 Uchida reported that plasma catecholamine levels were dependent on the time from initiation of stress to blood collection.…”

Section: Catecholamines and Ec Apoptosissupporting

confidence: 61%

Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy

Uchida

Egami²,

Uchida

et al. 2010

Clinical Cardiology

View full text Add to dashboard Cite

Background: Takotsubo cardiomyopathy (TCM) is characterized by systolic ballooning of the left ventricular apex. It is triggered by emotional or physical stress, but the exact mechanism through which stress leads to TCM is not known. Hypothesis: Coronary microvessel apoptosis is the missing link between stress and TCM. Methods: In 8 female patients with TCM, plasma catecholamines,Thrombolysis in Myocardial Infarction (TIMI) coronary flow grade and myocardial perfusion grade, and apoptosis of the coronary microvessels in the biopsied myocardial specimen by terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) were examined. Results: Plasma epinephrine and norepinephrine were increased to 663 ± 445 and 875 ± 812 pg/mL (mean ± SD), respectively. Acetylcholine-induced delayed myocardial perfusion through the ballooning apical segment without flow disturbance in the epicardial coronary arteries (indicating microvessel spasm) and focal myocardial necrosis were observed in all subjects. Apical ballooning disappeared and myocardial perfusion delay was not inducible 1 month later. The number of vessels having apoptotic endothelial cells/10 vessels in arterioles, venules, and capillaries at initial biopsy and repeat biopsy 1 month later were 8.3 ± 1.4 vs 0.4 ± 1.1, P < 0.0001; 6.8 ± 1.8 vs 0.3 ± 0.7, P < 0.0001; and 7.9 ± 1.0 vs 0.5 ± 0.9, P < 0.0001, respectively. Conclusions: Left ventricular apical ballooning in TCM was considered to be caused by coronary microvessel spasm due to catecholamine-induced endothelial cell apoptosis and myocardial stunning after release of microvessel spasm. Endothelial cell apoptosis of coronary microvessel is therefore considered to be the missing link between stress and TCM.

show abstract

Section: Catecholamines and Ec Apoptosissupporting

confidence: 61%

Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy

Uchida

Egami²,

Uchida

et al. 2010

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…Its onset is rare; however, its specific features play an important role in diagnosing the chest pain in clinical practice. Transient left ventricular (LV) wall motion abnormalities are peculiar in TTC and these abnormalities are not triggered by obstructive coronary artery disease (3)(4)(5)(6)(7). Post menopausal patients under emotional and physical stress predominantly suffer from this syndrome.…”

Section: Introductionmentioning

confidence: 99%

Role of echocardiography for takotsubo cardiomyopathy: clinical and prognostic implications

Izumo¹,

Akashi²

2018

Cardiovasc. Diagn. Ther.

View full text Add to dashboard Cite

Takotsubo cardiomyopathy (TTC) is newly-described secondary cardiomyopathy characterized by transient left ventricular (LV) dysfunction, which is increasingly recognized in the field of cardiology.TTC occurs in approximately 2% of the patients with acute coronary syndrome. Its onset is rare; however, its specific features play a crucial role in diagnosing the chest pain in clinical practice. TTC has generally favorable outcome with rapid recovery of LV function; however, an increasing evidence suggests that it should be regarded as a more serious acute cardiac disorder with a variety of complications. Owing to its widespread availability, even in emergency settings, transthoracic echocardiography plays a key role in the diagnostic assessment of TTC and contributes to an increased number of disease detection and incidence reports in contemporary clinical practice. This review focuses on the role of echocardiography in understanding the clinical prognostic implications in patients with TTC.

show abstract

“…The classical course of TTC is "spontaneously reversible" left ventricular (LV) systolic dysfunction: initially hypokinetic/akinetic (usually apical) regions recover to apparently normal wall motion within days in most cases 8,9 .…”

mentioning

confidence: 99%

Relation of Delayed Recovery of Myocardial Function After Takotsubo Cardiomyopathy to Subsequent Quality of Life

Neil

Nguyen

Singh

et al. 2015

The American Journal of Cardiology

View full text Add to dashboard Cite

Reversible Ventricular Dysfunction Takotsubo (ampulla-shaped) Cardiomyopathy

Cited by 41 publications

References 13 publications

Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy

Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy

Role of echocardiography for takotsubo cardiomyopathy: clinical and prognostic implications

Relation of Delayed Recovery of Myocardial Function After Takotsubo Cardiomyopathy to Subsequent Quality of Life

Contact Info

Product

Resources

About