Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Li, Yuling; Zhu, Li; Liu, Zhaozhong; Cheng, Ru; Meng, Fenghua; Cui, Jie; Ji, Shun‐Jun; Zhong, Zhiyuan

doi:10.1002/anie.200904260

Cited by 426 publications

(325 citation statements)

References 47 publications

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“…To achieve this goal, continuous efforts have been dedicated to the development of stimuli-responsive nanoplatforms. [2] Environmental stimuli that were exploited include pH, [3] temperature, [4] enzymatic expression, [5] redox reaction, [6] and light. [7] Among these activating signals, pH triggers belong to the most extensively studied stimuli based on two types of differences in pH: a) pathological (e.g.…”

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confidence: 99%

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Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

et al. 2011

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Umgebungseinfluss: Anpassbare, pH‐responsive Nanopartikel können selektiv in endozytischen Kompartimenten aktiviert werden. Bei hohen pH‐Werten bewirkt die Micellenbildung (links im Bild) eine Fluoreszenzlöschung durch Förster‐Energietransfer. Bei niedrigen pH‐Werten lösen sich die Micellen auf, was zu Fluoreszenz führt. Diese nichtlineare An/Aus‐Nanoplattform sollte für die diagnostische Bildgebung und den Wirkstofftransport interessant sein.

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confidence: 99%

“…Illustration of tunable, ultra-pH-responsive properties of pHAM nanoprobes. a) Representative fluorescence images of different nanoprobe solutions (6,3,4) at the same polymer concentration (0.1 mg mL À1 ) but different pH values. A narrow pH response is observed for each nanoprobe at different transition pH values.…”

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confidence: 99%

Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

et al. 2011

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“…[12] This large difference has been exploited for disulfide-triggered delivery in biotherapeutics. [6] A variety of DDS, including polymeric micelles, [13] nanogels [14] and nanoparticles [15] have been prepared base on this strategy. For example, Sun et al prepared disulfide linked polymeric micelles as drug carriers for drug controlled release.…”

Section: Introductionmentioning

confidence: 99%

Dual Stimuli‐Responsive Polymeric Micelles Exhibiting “AND” Logic Gate for Controlled Release of Adriamycin

Wei

Guo

Wang

2011

Macromol. Rapid Commun.

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A new controlled release polymer micelle was designed and synthesized based on the concept of the "AND" logic with two orthogonal molecular triggers, namely pH and reduction, for intracellular drug delivery. Specifically, a hydrazine functionalized PEO-b-PMAA block copolymer was used to attach adriamycin (ADR) through the formation of hydrazone, then the as-prepared ADR-conjugated block copolymer micelles could be crosslinked by dithiodiethanoic acid. ADR was found to release most efficiently under both the low pH and the reductive conditions. This smart device is therefore equipped with two triggers with the "AND" logic for the releasing action, which is suitable for more complicated physiological conditions because the "ON" state is only realized under the simultaneous presence of the dual signal stimuli.

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“…[5][6][7][8] They can be prepared by the partial hydrophobic modifications of biopolymers that result in amphiphilic character and consequently induce the self-assembly of biopolymers into NPs. [9][10] Nonetheless, the covalent modification processes are usually quite complicated and time consuming and thus it is virtually inconvenient to control the We present here a facile strategy for constructing Dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) through a radical polymerization of the monomer 3-acrylamidophenylboronic acid (APBA) bound by dextran via a boronic acid-diol reaction in aqueous solution. The synthesized Dextran-PAPBA NPs are stable in a wide pH range.…”

Section: Introductionmentioning

confidence: 99%

A Facile Strategy for Constructing Boron‐Rich Polymer Nanoparticles via a Boronic Acid‐Related Reaction

Zhang

Lin

Wang

et al. 2011

Macromol. Rapid Commun.

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We present here a facile strategy for constructing Dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) through a radical polymerization of the monomer 3-acrylamidophenylboronic acid (APBA) bound by dextran via a boronic acid-diol reaction in aqueous solution. The synthesized Dextran-PAPBA NPs are stable in a wide pH range. Their size and composition are tunable by varying the feeding molar ratio of the glucopyranoside unit in dextran to APBA. Additionally, the NPs have good biocompatibility and cell membrane penetrability, as demonstrated by in vitro experiments. Doxorubicin was encapsulated in the NPs and exhibited a sustained and strongly pH-dependent release profile that would greatly favor the in vivo drug delivery performance of the NPs. The facility of this strategy together with the tunable boron content and outstanding drug release and cellular membrane crossing performance of the produced NPs should greatly boost their applications in boron neutron capture therapy (BNCT) and chemotherapy for cancer treatment.

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Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Cited by 426 publications

References 47 publications

Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

Tunable, Ultrasensitive pH‐Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

Dual Stimuli‐Responsive Polymeric Micelles Exhibiting “AND” Logic Gate for Controlled Release of Adriamycin

A Facile Strategy for Constructing Boron‐Rich Polymer Nanoparticles via a Boronic Acid‐Related Reaction

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