Reversing the systemic biotoxicity of nanomaterials by downregulating ROS-related signaling pathways in the multi-organs of Zebrafish embryos

Zheng, Bin; Guo, Mingming; Song, Xin; Miao, Yaodong; Pang, Meijun; Ming, Dong

doi:10.1039/d1qm00193k

Cited by 7 publications

(4 citation statements)

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“…As ubiquitous antioxidant enzymes that scavenge ROS generated by bio‐oxidation, superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione‐S‐transferase (GST) play significant roles in safeguarding organisms' proper function and managing membrane lipid peroxidation. These antioxidant enzymes, as well as the lipid peroxide malondialdehyde (MDA) formed during the antioxidant process, are utilized as biomarkers for harmful chemicals that cause oxidative stress (Deng et al, 2019; Zheng, Guo, et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Progress on the toxicity of quantum dots to model organism‐zebrafish

Bai

Tang

2022

J of Applied Toxicology

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In vivo toxicological studies are currently necessary to analyze the probable dangers of quantum dots (QDs) to the environment and human safety, due to the fast expansion of QDs in a range of applications. Because of its high fecundity, cost-effectiveness, well-defined developmental phases, and optical transparency, zebrafish has long been considered the "gold standard" for biosafety assessment of chemical substances and pollutants. In this review, the advantages of using zebrafish in QD toxicity assessment were explored. Then, the target organ toxicities such as developmental toxicity, immunotoxicity, cardiovascular toxicity, neurotoxicity, and hepatotoxicity were summarized. The hazardous effects of different QDs, including cadmium-containing QDs like CdTe, CdSe, and CdSe/ZnS, as well as cadmium-free QDs like graphene QDs (GQDs), graphene oxide QDs (GOQDs), and others, were emphasized and described in detail, as well as the underlying mechanisms of QDs generating these effects.Furthermore, general physicochemical parameters determining QD-induced toxicity in zebrafish were introduced, such as chemical composition and surface coating/ modification. The limitations and special concerns of using zebrafish in QD toxicity studies were also mentioned. Finally, we predicted that the utilization of high-throughput screening assays and omics, such as transcriptome sequencing, proteomics, and metabolomics will be popular topic in nanotoxicology.cadmium-containing quantum dots, cadmium-free quantum dots, nanotoxicity, quantum dots, zebrafish model | INTRODUCTIONQuantum dots (QDs) are a type of semiconductor nanoparticle (typically 1-10 nm in diameter) that exhibit a number of features, including size effect, specific surface effect, and macroscopic quantum tunneling effect (Alivisatos, 1996). Group II-VI elements (e.g., CdTe, CdSe, CdS, ZnS, ZnSe, or ZnTe), group III-V elements (e.g., InP or InAs), group I-III-VI2 elements (e.g., CuInS 2 or AgInS 2 ), and group IV-VI elements (e.g., PbSe, PbS, or PbS) are common chemical components (Xu et al., 2016). As fluorescent nanomaterials, several varieties of QDs with a range of unique features are generated and widely used. Photonic applications such as light-emitting diodes (LEDs), organic LEDs (OLEDs), and solar cells have long used QDs (Choi et al., 2013;Steckel et al., 2006;Yuan et al., 2018). The use of QDs in biomedicine has sparked a lot of attention in recent years. QDs have been employed in a variety of biomedical applications, including cell markers and biological imaging (Singh et al., 2019;Wagner et al., 2019). QDs have a variety of benefits over traditional molecular dyes. Organic molecules degrade with time, whereas inorganic crystallites can withstand several excitations and light emissions. Long-term stability allows researchers to examine cells and tissues over long periods while maintaining the capacity to alter the interface quickly (Yang et al., 2019).Another advantage of QDs is that they are rich in colors. Because of the complexity of biological systems, it ...

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Section: Discussionmentioning

confidence: 99%

“…proper function and managing membrane lipid peroxidation. These antioxidant enzymes, as well as the lipid peroxide malondialdehyde (MDA) formed during the antioxidant process, are utilized as biomarkers for harmful chemicals that cause oxidative stress (Deng et al, 2019;Zheng, Guo, et al, 2021).…”

Section: Zarcomentioning

confidence: 99%

Progress on the toxicity of quantum dots to model organism‐zebrafish

Bai

Tang

2022

J of Applied Toxicology

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“…73 In another study, CdSe quantum dots modified with polyethylene glycol (PEG) can reduce oxidative stress and ROS levels, protect the heart and blood vessels, and have good biocompatibility. 74 Similarly, the protective effect of PEGylated GQDs on myocardial infarction is dose-dependent, which is mediated by strengthening the cardiac antioxidant defense system. 75…”

Section: Cytotoxicity Of Quantum Dotsmentioning

confidence: 99%

Research progress in the synthesis and biological application of quantum dots

Zhang

Liu

et al. 2022

New J. Chem.

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“…It can also be deaminated by adenosine deaminase (ADA) to form 7-deaza-inosine (preQ0), which can be further converted to 7-deazaguanine derivatives. Finally, it can be degraded by purine nucleoside phosphorylase (PNP) to form hypoxanthine and ribose-1-phosphate. − Cellular kinases phosphorylate tubercidin, converting Tub into its triphosphate form, which inhibits protein expression and tumor activity upon integration into DNA or RNA. , …”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Membrane-Camouflaged Polydopamine and Bioactive Glass Composite Nanoformulation for Combined Chemo/Chemodynamic/Photothermal Therapy

Zhang,

Sun,

Ren

et al. 2023

ACS Biomater. Sci. Eng.

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Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT), are needed to effectively address evolving drug resistance and the adverse effects of traditional cancer treatment. Herein, a camouflage composite nanoformulation (TCBG@PR), an antitumor agent (tubercidin, Tub) loaded into Cu-doped bioactive glasses (CBGs) and subsequently camouflaged by polydopamine (PDA), and red blood cell membranes (RBCm), was successfully constructed for targeted and synergetic antitumor therapies by combining CT of Tub, CDT of doped copper ions, and PTT of PDA. In addition, the TCBG@PRs composite nanoformulation was camouflaged with a red blood cell membrane (RBCm) to improve biocompatibility, longer blood retention times, and excellent cellular uptake properties. It integrated with long circulation and multimodal synergistic treatment (CT, CDT, and PTT) with the benefit of RBCms to avoid immune clearance for efficient targeted delivery to tumor locations, producing an "all-in-one" nanoplatform. In vivo results showed that the TCBG@PRs composite nanoformulation prolonged blood circulation and improved tumor accumulation. The combination of CT, CDT, and PTT therapies enhanced the antitumor therapeutic activity, and light-triggered drug release reduced systematic toxicity and increased synergistic antitumor effects.

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Reversing the systemic biotoxicity of nanomaterials by downregulating ROS-related signaling pathways in the multi-organs of Zebrafish embryos

Abstract: Nanomaterials have broad application prospects in human health and diseases, such as medical imaging and drug delivery and treatment. With the gradual advent of the nano era, the safety of...

Cited by 7 publications

References 50 publications

Progress on the toxicity of quantum dots to model organism‐zebrafish

Progress on the toxicity of quantum dots to model organism‐zebrafish

Research progress in the synthesis and biological application of quantum dots

Red Blood Cell Membrane-Camouflaged Polydopamine and Bioactive Glass Composite Nanoformulation for Combined Chemo/Chemodynamic/Photothermal Therapy

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