Review: African medicinal plants with wound healing properties

Agyare, Christian; Boakye, Yaw Duah; Bekoe, Emelia Oppong; Hensel, Andreas; Dapaah, Susana Oteng; Appiah, Theresa

doi:10.1016/j.jep.2015.11.008

Cited by 120 publications

(83 citation statements)

References 86 publications

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“…Development of potential therapeutic drugs from natural materials to accelerate wound healing will be useful for treating wounds (Jaric et al, 2018;Agyare et al, 2016). Natural resources provide cost-effective, accessible and reliable medical substances.…”

Section: Introductionmentioning

confidence: 99%

The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis

Yang

Sun

Zhang

et al. 2019

Journal of Ethnopharmacology

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A B S T R A C TEthnopharmacological relevance: Disposed earthworm has been used to treat various common ailments including burns, arthritis, itching, and inflammation for thousands of years in China. As their remarkable ability to fully regenerate in a scar-free manner, regenerated tissue homogenate of amputated Eisenia fetida (E. fetida) have been considered as an excellent wound repair therapy in our previous study. We have demonstrated that regenerated earthworm (G-90') can perform higher wound repair ability to non-regeneration tissue (G-90) through significant promotion of cutaneous wound repair in mice after their administration into wound beds. Objective: In the present study, we aimed to reveal the mechanism of G-90' and to explore a potential wound healing accelerated strategy. Methods and results: Two functional proteins-HSP70 and lysozyme in G-90′ were confirmed by cross-identification of LC-MS/MS and transcriptome analyses. Followed with semi-quantitative PCR and western blot, their expression were validated to up-regulate in 3-day regenerated tissues (G-90'). Conclusion: This study implies the therapeutic potency of G-90' for wound recovery and provides a new strategy to assess other natural materials targeting wound healing with the tail-amputated E .fetida as a model organism.

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Section: Introductionmentioning

confidence: 99%

The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis

Yang

Sun

Zhang

et al. 2019

Journal of Ethnopharmacology

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“…Medicinal plants have been used in medicine since ancient times and are well known for their abilities to promote wound healing without severe side effects. These herbal remedies could be considered as future drugs for healing of wounds (Agyare et al, 2016;Hosein et al, 2014). In the light of this, and the needs of the pharmaceutical market, wound healing agents originating from natural products, used in traditional medicine, has advanced tremendously in academia and are a major interest of pharmaceutical industry (Budovsky et al, 2015;Maver et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Struthanthus vulgaris ointment prevents an over expression of inflammatory response and accelerates the cutaneous wound healing

Gramma

Marques

Vittorazzi

et al. 2016

Journal of Ethnopharmacology

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“…Also this extracts can use in treatment leukemia and sickle cell disorder [6]- [8]. Also The studies showed the extracts of the different plants can be use to treat cancer-like symptoms [9].…”

Section: Introductionmentioning

confidence: 97%

The Effects of Scrophularia striata Extract on HEK Cell Line in Cell Culture

2016

2016 International Conference on Biological and Environmental Science (BIOES-16) June 8-9, 2016 New Jersey (USA)

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Review: African medicinal plants with wound healing properties

Cited by 120 publications

References 86 publications

The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis

The up-regulation of two identified wound healing specific proteins-HSP70 and lysozyme in regenerated Eisenia fetida through transcriptome analysis

Struthanthus vulgaris ointment prevents an over expression of inflammatory response and accelerates the cutaneous wound healing

The Effects of Scrophularia striata Extract on HEK Cell Line in Cell Culture

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