This Waste Isolation Pilot Plant (WIPP) Annual Site Environmental Report for 2010 presents summary environmental data to (1) characterize site environmental management performance, (2) summarize environmental occurrences and responses reported during the calendar year, (3) confirm compliance with environmental standards and requirements, and (4) highlight the WIPP Environmental Management System (EMS), significant environmental programs, and accomplishments including progress toward the DOE Environmental Sustainability Goals. It is important that the information we provide is easily understood, of interest, and communicates WIPP's efforts to protect human health and minimize our impact on the environment. We would like to know from you whether we are successful in achieving these goals. Your comments are appreciated and will help us to improve our communications.