Review and Perspective on Brain Bases of Tinnitus

Husain, Fatima T.; Khan, Rafay A.

doi:10.1007/s10162-023-00914-1

Cited by 6 publications

(4 citation statements)

References 105 publications

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“…They do not explain the fact that not all individuals with hearing loss develop tinnitus. In order to clarify this observation, it is essential to look into biological factors such as genetics 24 and cerebral functioning 25 which extend beyond the scope of this study.…”

Section: Discussionmentioning

confidence: 99%

Tinnitus risk factors and its evolution over time: a cohort study

Hobeika,

Fillingim,

Tanguay-Sabourin

et al. 2024

Preprint

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BackgroundSubjective tinnitus is an auditory percept unrelated to an external sound source. The lack of curative treatments and limited understanding of its risk factors complicate the prevention and management of this distressing symptom. This study seeks to identify socio-demographic, psychological, and health-related risk factors predicting tinnitus presence (how often individuals perceive tinnitus) and severity separately, and their evolution over time.MethodsUsing the UK Biobank dataset which encompasses data on the socio-demographic, physical, mental and hearing health from more than 170,000 participants, we trained two distinct machine learning models to identify risk scores predicting tinnitus presence and severity separately. These models were used to predict tinnitus over time and were replicated in 463 individuals from the Tinnitus Research Initiative database.FindingMachine learning based approach identified hearing health as a primary risk factor for the presence and severity of tinnitus, while mood, neuroticism, hearing health, and sleep only predicted tinnitus severity. Only the severity model accurately predicted the evolution over nine years, with a large effect size for individuals developing severe tinnitus (Cohen’sd= 1.10, AUC-ROC = 0.70). To facilitate its clinical applications, we simplified the severity model and validated a five-item questionnaire to detect individuals at risk of developing severe tinnitus.InterpretationThis study is the first to clearly identify risk factors predicting tinnitus presence and severity separately. Hearing health emerges as a major predictor of tinnitus presence, while mental health plays a crucial role in its severity. The successful prediction of the evolution of tinnitus severity over nine years based on socio-emotional, hearing and sleep factors suggests that modifying these factors could mitigate the impact of tinnitus. The newly developed questionnaire represents a significant advancement in identifying individuals at risk of severe tinnitus, for which early supportive care would be crucial.FundingHorizon Europe Marie Slodowska-Curie Actions, the Fondation des gueules cassées, the Fondation pour l’Audition, the Louise and Alan Edwards Foundation, the Canadian Institutes Health Research, the Institut TransMedTech and the Canada First Research Excellence Fund.

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Section: Discussionmentioning

confidence: 99%

Tinnitus risk factors and its evolution over time: a cohort study

Hobeika,

Fillingim,

Tanguay-Sabourin

et al. 2024

Preprint

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“…Indeed, although mechanisms of tinnitus are investigated with network science and conceived about distinct disciplines such as audiology, biology, psychology, and physiology, no study to date has attempted to offer a multidisciplinary integrated neurophysiological, psychological, and audiological approach in an ecological in vivo experimental setting. Although numerous neuroscientific techniques have been used to investigate the pathology of tinnitus at the brain level ([ 74 ] for a review) and several paradigms have been applied to assess neural correlates of tinnitus [ 75 ], only a few experimental paradigms [ 76 ] have attempted to recreate the everyday ecological context of the tinnitus-perceiving patient.…”

Section: Introductionmentioning

confidence: 99%

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

Inguscio,

Rossi,

Giliberto

et al. 2024

Brain Sciences

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Background: Despite substantial progress in investigating its psychophysical complexity, tinnitus remains a scientific and clinical enigma. The present study, through an ecological and multidisciplinary approach, aims to identify associations between electroencephalographic (EEG) and psycho-audiological variables. Methods: EEG beta activity, often related to stress and anxiety, was acquired from 12 tinnitus patients (TIN group) and 7 controls (CONT group) during an audio cognitive task and at rest. We also investigated psychological (SCL-90-R; STAI-Y; BFI-10) and audiological (THI; TQ12-I; Hyperacusis) variables using non-parametric statistics to assess differences and relationships between and within groups. Results: In the TIN group, frontal beta activity positively correlated with hyperacusis, parietal activity, and trait anxiety; the latter is also associated with depression in CONT. Significant differences in paranoid ideation and openness were found between groups. Conclusions: The connection between anxiety trait, beta activity in the fronto-parietal cortices and hyperacusis provides insights into brain functioning in tinnitus patients, offering quantitative descriptions for clinicians and new multidisciplinary treatment hypotheses.

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“…A recent animal study of auditory threat learning has shown that a selective plasticity in auditory corticoamygdalar projection neurons asymmetrically increased corticofugal spike-LFP coupling and sound-evoked activity in the lateral amygdala 34 , suggesting that increased neural gain in cortical projection neurons can be passed on to postsynaptic brain regions that regulate affective evaluation of valence and arousal. To this point, several neuroimaging studies in participants with tinnitus and sound sensitivity have identified abnormally strong coupling between auditory cortex and the amygdala, insula, anterior cingulate cortex, and medial prefrontal cortex 33,[35][36][37] . Whereas psychoacoustic and low-level auditory assays were generally not correlated with extra-auditory features of sound aversion and psychological burden [38][39][40][41][42][43] , neuroimaging assays of enhanced coupling with extra-auditory networks have shown stronger correlations with individual differences in tinnitus and sound sensitivity severity 37,44 .…”

Section: Introductionmentioning

confidence: 99%

“…To this point, several neuroimaging studies in participants with tinnitus and sound sensitivity have identified abnormally strong coupling between auditory cortex and the amygdala, insula, anterior cingulate cortex, and medial prefrontal cortex 33,[35][36][37] . Whereas psychoacoustic and low-level auditory assays were generally not correlated with extra-auditory features of sound aversion and psychological burden [38][39][40][41][42][43] , neuroimaging assays of enhanced coupling with extra-auditory networks have shown stronger correlations with individual differences in tinnitus and sound sensitivity severity 37,44 .…”

Section: Introductionmentioning

confidence: 99%

The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders

Smith,

Jahn,

Sugai

et al. 2023

Preprint

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SummaryCentral disinhibition works like an amplifier, boosting neural sensitivity to progressively weaker peripheral inputs arising from degenerating sensory organs. The Excess Central Gain model posits that central disinhibition also gives rise to cardinal features of sensory disorders including sensory overload and phantom percepts. Here, we tested predictions of this model with neural, autonomic, and behavioral approaches in participants with sound sensitivity and tinnitus (phantom ringing). We confirmed enhanced auditory neural gain but found no association with their sound aversion and anxiety. Instead, we hypothesized that symptom severity was linked to affective sound encoding. In neurotypical controls, emotionally evocative sounds elicited pupil dilations, electrodermal responses and facial reactions that scaled with valence. Participants with disordered hearing exhibited disrupted pupil and facial reactivity that accurately predicted their self-reported tinnitus and hyperacusis severity. These findings highlight auditory-limbic dysregulation in tinnitus and sound sensitivity disorders and introduce approaches for their objective measurement.

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Review and Perspective on Brain Bases of Tinnitus

Cited by 6 publications

References 105 publications

Tinnitus risk factors and its evolution over time: a cohort study

Tinnitus risk factors and its evolution over time: a cohort study

Bridging the Gap between Psychophysiological and Audiological Factors in the Assessment of Tinnitus: An EEG Investigation in the Beta Band

The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders

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