Review: antimicrobial properties of allicin used alone or in combination with other medications

Choo, Sulin; Chin, Voon Kin; Wong, Eng Hwa; Madhavan, Priya; Tay, Sun Tee; Yong, Phelim Voon Chen; Chong, Pei Pei

doi:10.1007/s12223-020-00786-5

Cited by 65 publications

(57 citation statements)

References 114 publications

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“…The synergistic effect of TSFs and GLSs in combination with conventional antimicrobial agents against pathogenic bacteria was observed in most studies. For example, allicin shows synergistic and adjuvant activity with antibiotics such as oxacillin and cefazolin against S. aureus and P. aeruginosa [ 239 ]. Allicin-β-lactam combinations offer the promise of clinical utility, especially when synergism is demonstrated by in vivo experimental studies [ 240 ].…”

Section: Alternatives To Conventional Antibiotics Used To Treat Bacterial Skin Infections In Animalsmentioning

confidence: 99%

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Malá

Laloučková

Skřivanová

2021

Animals

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Due to its large surface area, the skin is susceptible to various injuries, possibly accompanied by the entrance of infective agents into the body. Commensal organisms that constitute the skin microbiota play important roles in the orchestration of cutaneous homeostasis and immune competence. The opportunistic pathogen Staphylococcus aureus is present as part of the normal biota of the skin and mucous membranes in both humans and animals, but can cause disease when it invades the body either due to trauma or because of the impaired immune response of the host. Colonization of livestock skin by S. aureus is a precursor for majority of bacterial skin infections, which range from boils to sepsis, with the best-characterized being bovine mastitis. Antibiotic treatment of these infections can contribute to the promotion of resistant bacterial strains and even to multidrug resistance. The development of antibiotic resistance to currently available antibiotics is a worldwide problem. Considering the increasing ability of bacteria to effectively resist antibacterial agents, it is important to reduce the livestock consumption of antibiotics to preserve antibiotic effectiveness in the future. Plants are recognized as sources of various bioactive substances, including antibacterial activity towards clinically important microorganisms. This review provides an overview of the current knowledge on the major groups of phytochemicals with antibacterial activity and their modes of action. It also provides a list of currently known and used plant species aimed at treating or preventing bacterial skin infections in livestock.

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Section: Alternatives To Conventional Antibiotics Used To Treat Bacterial Skin Infections In Animalsmentioning

confidence: 99%

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Malá

Laloučková

Skřivanová

2021

Animals

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“…Garlic has been studied extensively with regard to its chemistry, pharmacology and clinical properties. The main research interests lie in the area of anticancer, antimicrobial and cardiovascular effects [24,25]. The sulphur-containing compounds within garlic are considered responsible for the varied bioactive effects.…”

Section: Common Foodsmentioning

confidence: 99%

“…With strong and long traditional use, garlic is often taken by patients in hope for quicker recovery. In common folklore, blogs and healthcare websites, garlic has a reputation to help with recovery from common cold to cancer [25,26]; this is at least in part supported by evidence. Though garlic is considered food, high dosage is commonly not recommended for older adults as there is a strong evidence for inhibiting effect on platelets [27].…”

Section: Common Foodsmentioning

confidence: 99%

Food-Drug Interaction in Older Adults

Aðalbjörnsson

Ramel

2021

Perspectives in Nursing Management and Care for Older Adults

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“…31 Allicin has been shown to demonstrate various antimicrobial activities in both in vitro and in vivo studies. 31,32,33 Recently, allicin was reported to exhibit a modulatory effect on the gut microbiota and reduced hepatic steatosis. 34,35 Additionally, our previous pilot study showed that allicin supplementation shaped the gut microbiota composition and reduced TMAO production by the gut microbiota in mice subjected to moderate carnitine consumption (0.02 %carnitine).…”

Section: Introductionmentioning

confidence: 99%

Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation

Sheen

Panyod

et al. 2021

Preprint

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Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO) formed from ʟ-carnitine. Raw garlic juice, with allicin as its primary compound, has been shown to powerfully impact the gut microbiota. This study validated the benefits of raw garlic juice against CVD risk via modulation of the gut microbiota and its metabolites. Allicin supplementation significantly decreased serum TMAO in ʟ-carnitine-fed C57BL/6J mice. It also reduced aortic lesions and altered the fecal microbiota in carnitine-induced, atherosclerosis-prone, apolipoprotein E-deficient mice. In human subjects exhibiting high TMAO production, raw garlic juice intake for a week reduced TMAO formation, improved gut microbial diversity, and increased the relative abundances of beneficial bacteria. In in vitro study, raw garlic juice inhibited γ-butyrobetaine (γBB) and trimethylamine (TMA) production by the gut microbiota. Thus, raw garlic juice can potentially prevent cardiovascular disease by decreasing TMAO production through gut microbiota modulation.

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Review: antimicrobial properties of allicin used alone or in combination with other medications

Cited by 65 publications

References 114 publications

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Food-Drug Interaction in Older Adults

Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation

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