Review Article; Duodeno-Gastro-Esophageal Reflux Combined and Isolated

Nasr,

doi:10.3844/amjsp.2013.127.142

Cited by 2 publications

(3 citation statements)

References 131 publications

(130 reference statements)

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“…However, their toxicity to airway mucosa is less well understood [12]. Patients with a range of airway diseases have been shown to exhibit higher BA concentrations in their bronchoalveolar lavage (BAL) [13].…”

Section: Introductionmentioning

confidence: 99%

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Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases

et al. 2017

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Gastro-oesophageal reflux and aspiration have been associated with chronic and end-stage lung disease and with allograft injury following lung transplantation. This raises the possibility that bile acids may cause lung injury by damaging airway epithelium. The aim of this study was to investigate the effect of bile acid challenge using the immortalised human bronchial epithelial cell line (BEAS-2B).The immortalised human bronchial epithelial cell line (BEAS-2B) was cultured. A 48-h challenge evaluated the effect of individual primary and secondary bile acids. Post-challenge concentrations of interleukin (IL)-8, IL-6 and granulocyte−macrophage colony-stimulating factor were measured using commercial ELISA kits. The viability of the BEAS-2B cells was measured using CellTiter-Blue and MTT assays.Lithocholic acid, deoxycholic acid, chenodeoxycholic acid and cholic acid were successfully used to stimulate cultured BEAS-2B cells at different concentrations. A concentration of lithocholic acid above 10 μmol·L−1 causes cell death, whereas deoxycholic acid, chenodeoxycholic acid and cholic acid above 30 μmol·L−1 was required for cell death. Challenge with bile acids at physiological levels also led to a significant increase in the release of IL-8 and IL6 from BEAS-2B.Aspiration of bile acids could potentially cause cell damage, cell death and inflammation in vivo. This is relevant to an integrated gastrointestinal and lung physiological paradigm of chronic lung disease, where reflux and aspiration are described in both chronic lung diseases and allograft injury.

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Section: Introductionmentioning

confidence: 99%

“…Gastric mucosa [ 8 , 9 ], colonic mucosa [ 9 , 10 ] and hepatocytes [ 11 ] are all affected by BAs. However, their toxicity to airway mucosa is less well understood [ 12 ]. Patients with a range of airway diseases have been shown to exhibit higher BA concentrations in their bronchoalveolar lavage (BAL) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases

et al. 2017

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“…The gastric mucosa, colon, and hepatocytes are affected by BAs [ 7 ]. However, their toxicity to the mucous membrane of the respiratory tract is not well understood [ 8 ]. Patients with a range of respiratory diseases have been shown to have higher BAs concentrations in their bronchoalveolar lavage [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Bile Acids in the Human Body and in the Development of Diseases

et al. 2022

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Bile acids are specific and quantitatively important organic components of bile, which are synthesized by hepatocytes from cholesterol and are involved in the osmotic process that ensures the outflow of bile. Bile acids include many varieties of amphipathic acid steroids. These are molecules that play a major role in the digestion of fats and the intestinal absorption of hydrophobic compounds and are also involved in the regulation of many functions of the liver, cholangiocytes, and extrahepatic tissues, acting essentially as hormones. The biological effects are realized through variable membrane or nuclear receptors. Hepatic synthesis, intestinal modifications, intestinal peristalsis and permeability, and receptor activity can affect the quantitative and qualitative bile acids composition significantly leading to extrahepatic pathologies. The complexity of bile acids receptors and the effects of cross-activations makes interpretation of the results of the studies rather difficult. In spite, this is a very perspective direction for pharmacology.

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Review Article; Duodeno-Gastro-Esophageal Reflux Combined and Isolated

Cited by 2 publications

References 131 publications

Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases

Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases

The Role of Bile Acids in the Human Body and in the Development of Diseases

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