Review Article on Congenital Hypothyroidism and Newborn Screening Program in Africa; the Present Situation and the Way Forward

Adeniran, Kayode; Limbe, Mary

doi:10.4172/2167-7948.1000102

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…Obviously missing is Sub-Saharan Africa for which little information is currently available, and limited congenital hypothyroidism (CH) and sickle cell NBS activities are ongoing. [13][14][15] A review of the literature and personal contacts working in Africa revealed documentation of various beginning newborn screening activities in Ghana, 16,17 Nigeria, 18 Tanzania, 19 Angola, 20 Ethiopia, 21 Democratic Republic of Congo, 22 and South Africa. 23,24 For the remainder of the world, we have drawn on our extensive NBS experience and contacts with NBS program managers within our respective regions to solicit recent updates in order to comprehensively describe ongoing regional NBS activities.…”

Section: Introductionmentioning

confidence: 99%

Current status of newborn screening worldwide: 2015

Therrell

Padilla

Loeber³

et al. 2015

Seminars in Perinatology

482

418

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Section: Introductionmentioning

confidence: 99%

Current status of newborn screening worldwide: 2015

Therrell

Padilla

Loeber³

et al. 2015

Seminars in Perinatology

482

418

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“…The majority of newborns will appear normal and healthy so doctors may not suspect they have congenital hypothyroidism. 8, 9 Some things that can be noticed in infants with congenital hypothyroidism, namely in newborns up to the age of 8 weeks of non-specific complaints, developmental retardation, failure to thrive or short stature, lethargy, inactivity, constipation, lazy sucking, hoarse crying voice, pale, born in an area with a prevalence of endemic cretinism and an area of iodine deficiency, premature birth or more months (postmature), a family history of thyroid disorders, maternal illness during pregnancy, currently taking antithyroid drugs, and light therapy. Clinical manifestations that can be seen in congenital hypothyroidism include a large fontanelle or late closing, dull face, macroglossia, dry skin, umbilical hernia, mottling, cutis marmorata, decreased activity, jaundice, hypotonia, at first glance like Down's syndrome, but at a glance Down syndrome babies are more active, more common in infants with birth weight less than 2000 g or more than 4000 g, about 3-7% of infants with congenital hypothyroidism are usually accompanied by other congenital abnormalities, especially atrial and ventricular septal defects.…”

Section: Original Articlementioning

confidence: 99%

Screening for congenital hypothyroidism in Malang, East Java in 2020

Salim

Putri

Rosmalawati

et al. 2022

PEDSCIJ

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Introduction: Congenital hypothyroidism is defined as a state of thyroid hormone deficiency present at birth. Congenital hypothyroidism must be diagnosed immediately because delay in therapy may cause irreversible neurological deficits, such as mental retardation in children. However, this condition can be prevented by screening in newborns so that congenital hypothyroidism can be diagnosed and treated early, and can result in better neurological development. This study aims to determine the congenital hypothyroidism ratio in Malang from March to November 2020. Methods: The descriptive analysis method was used in this research. The subjects were neonates aged 0 – 28 days with a gestational age of 36 weeks and were involving the Health Office in both the Regency and the City of Malang. The data about identity, gender, age at screening, and gestational age were collected. A laboratory screening test was performed by taking a blood sample from the heel or vein for a TSH test. If the result was positive with a TSH value > 20 U/mL, the subject would be recalled for having a confirmation test and referred to a pediatric endocrinologist. Results: There were 2024 (88.34%) subjects were successfully screened from a total of 2291 subjects. The recall rate for congenital hypothyroidism was 1:2024 (0.04%). Conclusion: The ratio of congenital hypothyroidism cases in Malang from March to November 2020 was higher than the global ratio, which was 1:3000. The high rate of congenital hypothyroidism in Malang indicated the need for congenital hypothyroidism screening in newborns.

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“…16,3 Deficiencia TSH aislada •Mutación en el gen de la subunidad B de TSH). 16,6,34 Deficiencia de hormona liberadora de Tirotropina (TRH). 34 •Síndrome de interrupción del tallo hipofisario, lesión hipotalámica.…”

Section: Etiologíaunclassified

“…16,6,34 Deficiencia de hormona liberadora de Tirotropina (TRH). 34 •Síndrome de interrupción del tallo hipofisario, lesión hipotalámica. 16 Resistencia a TRH.…”

Section: Etiologíaunclassified

Hipotiroidismo congénito, la primera causa de retraso mental prevenible: un desafío para la medicina preventiva

Rincón

Rueda

et al. 2016

revmed

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Artículo recibido el 4 de julio de 2015 y aceptado para publicación el 12 de enero de 2016. RESUMENEl hipotiroidismo congénito es la enfermedad endocrina más frecuente en neonatos y puede ser de manifiesto clínico o subclínico. Es la principal causa de retraso mental tratable y su pronóstico radica en el tamizaje temprano y la instauración oportuna del tratamiento, por lo cual en Colombia se considera necesaria la implementación de un esquema de tamizaje neonatal con una técnica apropiada y de cobertura nacional, equiparable al de otros países. El objetivo de este artículo es realizar una revisión y análisis de la literatura médica existente sobre el hipotiroidismo congénito centrado en la definición, epidemiología, factores etiológicos, tamizaje, diagnóstico y tratamiento; mediante la búsqueda de artículos en las bases de datos PUBMED, EMBASE, REDALYC, OVID, MEDLINE, DYNAMED y CLINICAL KEY (acceso: mayo 2015). Además se realizó revisión de los informes del Instituto Nacional de Salud en el año 2013 y 2014, de las guías europeas de la sociedad de endocrinología pediátrica 2014, de la guía mexicana de hipotiroidismo congénito neonatal 2008 y del consenso colombiano para el diagnóstico y manejo de enfermedades tiroideas.

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Review Article on Congenital Hypothyroidism and Newborn Screening Program in Africa; the Present Situation and the Way Forward

Cited by 6 publications

References 34 publications

Current status of newborn screening worldwide: 2015

Current status of newborn screening worldwide: 2015

Screening for congenital hypothyroidism in Malang, East Java in 2020

Hipotiroidismo congénito, la primera causa de retraso mental prevenible: un desafío para la medicina preventiva

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