Review Article: Ophthalmic manifestations of multiple myeloma

Uveal effusion associated with an IgM lambda subtype monoclonal gammopathy

“…3 However, the present clinic case could be the first case described in the literature of uveal effusion associated to MGIS, a benign expression but a potential precursor of multiple myeloma.…”

Ocular crystal deposition leading to a diagnosis of multiple myeloma: a report of 2 cases and review of the literature

“…The pathophysiology of crystal deposition is still largely unclear, but is thought to be related to increased IgG levels (less commonly, IgA) in the tears, aqueous, and limbal vessels of the eye. This then manifests as crystalline deposits usually in the corneal epithelium or stroma, possibly due to spontaneous crystallization of the protein [2,7,8,9].…”

“…ciliary cysts, or immunoglobulin deposition [1,2,3]. More specifically, myeloma can cause crystalline or non-crystalline deposits in the cornea -this finding tends to occur during the late phase of the disease, but may be the initial manifestation of the underlying asymptomatic gammopathy [4,5].…”

Anticancer Role of PPARγAgonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes

“…The treatments include chemotherapy, radiation, or bone marrow transplantation. Ocular findings may be the first manifestation of MM [298]. It may also occur as one of the extramedullary manifestations of the disease or as the first sign of insufficient chemotherapy.…”

“…MM causes ocular pathology by direct infiltration or as extramedullary plasmacytomas resulting in the displacement or compression of tissues causing hyperviscosity syndrome and immunoglobulin light chain deposition in ocular tissues. Virtually any ocular structure can be affected, including the conjunctiva, cornea, sclera, lens, retina, optic nerve, lacrimal glands, and orbit [298] (Figure 5). …”