REVIEW: Behavioral evidence for the significance of serotoninergic (5‐HT) receptors in cocaine addiction

Filip, Małgorzata; Alenina, Natalia; Bäder, Michael; Przegaliński, Edmund

doi:10.1111/j.1369-1600.2010.00214.x

Cited by 84 publications

(54 citation statements)

References 179 publications

(331 reference statements)

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“…In addition to the sensitized effect at the DAT reported here, other systems appear to have a role in DA system sensitization, including glutamate (for a review, see Vanderschuren and Kalivas, 2000), GABA (for a review, see Steketee, 2005;Filip et al, 2006), and serotonin (Neumaier et al, 2002;Filip et al, 2010). Owing to the convergence of these systems and factors, which lead to the expression of behavioral sensitization, it remains to be determined whether increased DA overflow and behavioral effects would be seen after IntA self-administration.…”

Section: Discussionmentioning

confidence: 82%

“…An extensive literature, primarily using daily experimenteradministered intraperitoneal injections has documented neurochemical sensitization associated with the mesolimbic DA system Duffy, 1990, 1993;Parsons and Justice, 1993;Addy et al, 2010). Sensitization of cocaineinduced increases in extracellular DA has been linked not only to alterations in the regulation of DA release and reuptake (Jones et al, 1996;Addy et al, 2010), but also to influences such as glutamate (for a review, see Vanderschuren and Kalivas, 2000), GABA (for a review, see Steketee, 2005;Filip et al, 2006), and serotonin (Neumaier et al, 2002;Filip et al, 2010). By contrast, studies using self-administration procedures have generally shown tolerance to cocaine's DA-elevating and DAT-inhibiting effects.…”

Section: Introductionmentioning

confidence: 99%

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Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter

Calipari

Ferris

Zimmer

et al. 2013

Neuropsychopharmacol

164

121

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The dopamine transporter (DAT) is responsible for terminating dopamine (DA) signaling and is the primary site of cocaine's reinforcing actions. Cocaine self-administration has been shown previously to result in changes in cocaine potency at the DAT. To determine whether the DAT changes associated with self-administration are due to differences in intake levels or temporal patterns of cocaineinduced DAT inhibition, we manipulated cocaine access to produce either continuous or intermittent elevations in cocaine brain levels. Long-access (LgA, 6 h) and short-access (ShA, 2 h) continuous self-administration produced similar temporal profiles of cocaine intake that were sustained throughout the session; however, LgA had greater intake. ShA and intermittent-access (IntA, 6 h) produced the same intake, but different temporal profiles, with 'spiking' brain levels in IntA compared with constant levels in ShA. IntA consisted of 5-min access periods alternating with 25-min timeouts, which resulted in bursts of high responding followed by periods of no responding. DA release and uptake, as well as the potency of cocaine for DAT inhibition, were assessed by voltammetry in the nucleus accumbens slices following control, IntA, ShA, and LgA self-administration. Continuous-access protocols (LgA and ShA) did not change DA parameters, but the 'spiking' protocol (IntA) increased both release and uptake of DA. In addition, high continuous intake (LgA) produced tolerance to cocaine, while 'spiking' (IntA) produced sensitization, relative to ShA and naive controls. Thus, intake and pattern can both influence cocaine potency, and tolerance seems to be produced by high intake, while sensitization is produced by intermittent temporal patterns of intake.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter

Calipari

Ferris

Zimmer

et al. 2013

Neuropsychopharmacol

164

121

View full text Add to dashboard Cite

show abstract

“…Although previous studies have highlighted the role of 5-HT2cRs in psychostimulant action (Bubar and Cunningham, 2008), the consequences of drug exposure on these receptors has not been established to date (Filip et al, 2010). 5-HT2cRs control mesocorticolimbic DA activity (Di Matteo et al, 2002) and 5-HT2cRs expressed in the NAcbS modulate NAcb DA outflow (Navailles et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Cocaine Modulation of Frontostriatal Expression of Zif268, D2, and 5-HT2c Receptors in High and Low Impulsive Rats

Besson

Pelloux

Dilleen

et al. 2013

Neuropsychopharmacol

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Impulsivity shares high comorbidity with substance abuse in humans, and high impulsivity (HI) in rats has been identified as a predictive factor for cocaine addiction-like behavior. Despite the evidence that high impulsivity is associated with altered function of corticostriatal networks, the specific neural substrates underlying the increased vulnerability of impulsive individuals to develop cocaine addiction remain unknown. We therefore investigated specific neural correlates of HI within the corticostriatal circuitry and determined how they interact with a protracted history of cocaine self-administration. We used in situ hybridization to map brain expression of two major genes implicated in impulsivity, encoding the dopamine D2 receptor (DA D2R) and the 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity, zif268, in groups of rats selected for HI and low impulsivity (LI) on a 5-choice serial reaction time task (5-CSRTT) immediately after 5-CSRTT training, and following 10 or 50 days of cocaine self-administration. HI rats exhibited decreased DA D2R mRNA in the mesolimbic pathway, and increased 5-HT2cR mRNA in the orbitofrontal cortex compared with LI rats. HI rats also showed decreased zif268 mRNA in the ventral and dorsomedial striatum. Cocaine exposure decreased striatal D2R mRNA in both HI and LI rats, decreased 5-HT2cR mRNA differentially in striatal and prefrontal areas between HI and LI rats, and selectively decreased zif268 mRNA in the orbitofrontal and infralimbic cortices of HI animals. These findings implicate novel markers underlying the vulnerability of impulsive rats to cocaine addiction that localize to the OFC, infralimbic cortex, and striatum.

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“…Data from these transgenic lines suggest that the dopaminergic system interacts with serotoninergic signaling to infl uence the acquisition of cocaine CPP (Hnasko et al 2007). The involvement of serotonin and serotonin receptor subtypes in cocaine sensitization, discrimination, self-administration, reinstatement of cocaineseeking behavior, and CPP in laboratory animals has been reviewed elsewhere (Filip et al 2010).…”

Section: Modeling Drug Self-administration In Animalsmentioning

confidence: 99%

Advancing Addiction Treatment: What Can We Learn from Animal Studies?

Wu¹,

Schulz²

2012

ILAR Journal

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Substance addiction is a maladaptive behavior characterized by compulsive and uncontrolled self-administration of a substance (drug). Years of research indicate that addictive behavior is the result of complex interactions between the drug, the user, and the environment in which the drug is used; therefore, addiction cannot simply be attributed to the neurobiological actions of a drug. However, despite the obvious complexity of addictive behavior, animal models have both advanced understanding of addiction and contributed importantly to the development of medications to treat this disease. We briefl y review recent animal models used to study drug addiction and the contribution of data generated by these animal models for the clinical treatment of addictive disorders.

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REVIEW: Behavioral evidence for the significance of serotoninergic (5‐HT) receptors in cocaine addiction

Cited by 84 publications

References 179 publications

Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter

Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter

Cocaine Modulation of Frontostriatal Expression of Zif268, D2, and 5-HT2c Receptors in High and Low Impulsive Rats

Advancing Addiction Treatment: What Can We Learn from Animal Studies?

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