Review: Clinical and histological manifestations of canine atopic dermatitis

Bizikova, Petra; Santoro, Domenico; Marsella, Rosanna; Nuttall, Tim; Eisenschenk, Melissa; Pucheu‐Haston, Cherie M.

doi:10.1111/vde.12196

Cited by 59 publications

(61 citation statements)

References 23 publications

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“…No effect of gender on the risk of owner-reported allergic/atopic skin symptoms or verified CAD was detected in the present study. The most recent review agrees that CAD, in general, fails to exhibit sex predilection [74]. …”

Section: Discussionmentioning

confidence: 99%

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

2017

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The aim of this cross-sectional study was to observe whether environmental factors and phenotypic traits are associated with owner-reported skin problems and with veterinary diagnosed canine atopic dermatitis (CAD). Data were collected using the validated online DOGRISK questionnaire. Out of the data that the questionnaire provides for analysis, focus was first turned towards addressing questions regarding ‘Atopy/allergy (skin symptoms)’ using a total of 8643 dogs: 1585 dogs with owner-reported allergic/atopic skin symptoms and 7058 dogs without. A subsequent analysis compared dogs with veterinary-verified CAD (n = 322) as a case group against the 7058 dogs without owner-reported skin symptoms. The association between 21 factors related to the environment, canine phenotypes and breed groups within both populations were analysed using univariable and multivariable logistic regression. The environmental factors that showed a significant inverse association with the risk of owner-reported allergic/atopic skin symptoms were as following: whether the dog was living in a detached house, whether there were other dogs in the household, and whether the dog was born in the current household. Having over 50% white colour in the coat and living in an extremely clean household were significantly associated with an increased risk of owner-reported allergic/atopic skin symptoms. The five breeds demonstrating the highest proportion of owner-reported allergic/atopic skin symptoms were West Highland white terrier, Boxer, English bulldog, Dalmatian and French bulldog. The Fédération Cynologique Internationale dog breed groups 3 (Terriers) and 6 (Scent hounds and related breeds) showed a significantly higher risk for owner-reported allergic/atopic skin symptoms than mixed breed dogs. In the second population, the inverse association was observed between the risk of CAD and the presence of other dogs in the household, and whether the dog had been born in the current household. The results indicate that some environmental factors and canine phenotypes are associated with CAD and owner-reported skin symptoms, but they still do not prove causality.

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Section: Discussionmentioning

confidence: 99%

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

2017

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“…The clinical phenotype of atopic dermatitis varies among breeds, regions and countries. Previous studies have demonstrated that breeds such as the Labrador Retriever, Golden Retriever (GR), German Shepherd Dog (GSD), West Highland White Terrier (WHWT), Boxer, Cocker Spaniel, Bichon Frise, Shar‐pei and Scottish Terrier are genetically predisposed to CAD . The clinical presentation in some of these breeds has been documented briefly by Picco et al, and more extensively by Wilhem et al, who demonstrated the clinical phenotypes in nine often affected breeds of dog to highlight the variability of this allergic skin disease.…”

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confidence: 99%

“…Previous studies have demonstrated that breeds such as the Labrador Retriever, Golden Retriever (GR), German Shepherd Dog (GSD), West Highland White Terrier (WHWT), Boxer, Cocker Spaniel, Bichon Frise, Shar-pei and Scottish Terrier are genetically predisposed to CAD. [8][9][10][11][12] The clinical presentation in some of these breeds has been documented briefly by Picco et al, 9 and more extensively by Wilhem et al, 13 who demonstrated the clinical phenotypes in nine often affected breeds of dog to highlight the variability of this allergic skin disease. Those studies however, were completed in countries other than Australia and did not include several breeds of dog commonly owned in Australia such as the Staffordshire Bull Terrier (SBT), Australian Kelpie and Maltese Terrier.…”

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confidence: 99%

Lesion distribution in cases of canine atopic dermatitis in South Australia

2019

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Objective To determine the lesion distribution patterns in different breeds of dogs affected by atopic dermatitis in South Australia. Methods The presence or absence of erythematous skin lesions in 267 cases of canine atopic dermatitis (CAD) was recorded across 36 anatomical sites. Breeds represented by ≥ 9 dogs were included in the analysis. The percentage of dogs showing lesions at each of the body sites was calculated and illustrated on colour‐coded diagrams. Variations in affected body sites within and between breeds were compared using Kruskal‐Wallis ANOVA and Dunn's multiple comparison tests. Results The prevalence of skin lesions at different body sites differed significantly both in the population as a whole and within breeds. The sites affected in ≥ 75% dogs were the dorsal and ventral aspects of the front and hind paws. The sites affected in 50–74% were the medial pinnae, axillae, ventral chest, abdomen and perineum. Sites affected in 25–49% of dogs included the face, periocular region and forelimb. Remaining body sites were affected in < 25% of dogs. Analysis at the breed level revealed some differences from this standard distribution pattern. Conclusion The results of this study confirmed the typical lesion distributions seen in CAD and highlighted some subtle differences in breeds commonly seen in South Australia. This will be useful for clinical practitioners in prioritising differential diagnoses for pruritic skin conditions.

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“…Canine atopic dermatitis (CAD) is a common hypersensitivity in small animal practice. It is defined as a genetic predisposition to develop allergic skin disease associated with certain environmental factors leading to typical clinical signs and the formation of allergen‐specific IgE antibodies …”

Section: Introductionmentioning

confidence: 99%

The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo‐controlled study

Hobi

Klinger

Claßen

et al. 2017

Veterinary Dermatology

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Review: Clinical and histological manifestations of canine atopic dermatitis

Abstract: Considerable work has been done in recent years to provide a better definition of the clinical appearance and histopathology of canine AD. New sets of diagnostic criteria have been developed, and additional breed-associated differences in phenotypes have been demonstrated.

Cited by 59 publications

References 23 publications

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

Environmental and phenotype-related risk factors for owner-reported allergic/atopic skin symptoms and for canine atopic dermatitis verified by veterinarian in a Finnish dog population

Lesion distribution in cases of canine atopic dermatitis in South Australia

The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo‐controlled study

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