Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects

Liu, Jingjing; Zhan, Xiudan; Wan, Jian-Bo; Wang, Yitao; Wang, Chunming

doi:10.1016/j.carbpol.2014.11.063

Cited by 261 publications

(119 citation statements)

References 80 publications

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“…Hassan et al, also reported an increment of water uptake when introducing seaweed as fillers in polypropylene matrix [18]. Moreover, the presence of residual carrageenan inside the seaweed might also contribute to this phenomenon since the seaweed hydrocolloids are known to possess high water absorption capacity [29]. Similar findings were also reported for incorporation of other natural fibres i.e.…”

Section: Densitysupporting

confidence: 69%

Effect of seaweed on physical properties of thermoplastic sugar palm starch/agar composites

Jumaidin¹,

Sapuan²,

Jawaid³

et al. 2016

J. MECH. ENG. SCI.

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The aim of this paper is to investigate the physical properties of thermoplastic sugar palm starch/agar (TPSA) blend when incorporated with seaweed. The ratio of starch, agar, and glycerol for TPSA was maintained at 70:30:30. Seaweed with various contents (10,20,30, and 40 wt.%) were mixed with TPSA matrix via melt mixing before compression were molded into 3 mm plate at 140 o C for 10 minutes. The prepared laminates were characterized for moisture absorption, water absorption, thickness swelling, water solubility, and density. The results showed that increasing seaweed loading from 0 to 40 wt% has led to a drop in moisture content from 6.50 to 4.96% and 9% reduction of the density. TPSA matrix showed 52.5% water uptake and 32.3% swelling whereas TPSA/seaweed composites (40 wt% loading) showed 97% water uptake and 74.8% swelling respectively. Higher water solubility was also shown by TPSA/seaweed composites (57 wt%) compared to that of the TPSA matrix (26 wt%). After 16 days of storage, the equilibrium moisture content for TPSA and TPSA/seaweed (40 wt% loading) were 23.2 and 25.2% respectively. In conclusion, TPSA/seaweed composites show good environmental friendly characteristics as a renewable material. In future, the properties of this material can be further improved by hybridization with more hydrophobic fillers for better resistance against water.

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Section: Densitysupporting

confidence: 69%

Effect of seaweed on physical properties of thermoplastic sugar palm starch/agar composites

Jumaidin¹,

Sapuan²,

Jawaid³

et al. 2016

J. MECH. ENG. SCI.

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“…The same effect was observed when insulin was loaded in a carboxymethylated k-CRG nanocarrier, due to interactions with amino acids in insulin [ 34 ]. When the k-CRG was quaternized with 3-chloro-2-hydroxypropyltrimethyl ammonium chloride it afforded particles with both positive and negative charges which increased the loading capacity of the nanocarrier [ 35 ]. Electrostatic interactions with nanosized λ-CRG increased the solubility of a poorly soluble compound up to 30 times by converting it into an amorphous form upon inclusion into the complex [ 36 ].…”

Section: Carbohydrates and Polysaccharides From Honey And Seaweed In supporting

confidence: 67%

Bionanomaterials from Plant Sources

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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At the present an unprecedented interest in herbal healing is appearing everywhere. The Western world started to compare allopathic remedies (with many side effects) to the traditional ones and to acknowledge the latter as safer alternatives. In spite of their advantages, applications are slow to materialize, with poor solubility and low bioavailability being the main reasons. Natural products such as curcumin, hop extracts, essential oils are example of species with demonstrated biological activity but few applications due to unsatisfactory bioavailability correlated with low water solubility. Natural products with strong antioxidant effect, like polyphenols in teas, for example, are not widely used because of their sensitivity to oxidation (during processing and storage).Nanotechnology offers a huge promise for these compounds. The disadvantages mentioned disappear upon encapsulating them in nanosized carriers with appropriate chemistry. An added bonus thereof is the possibility of controlled delivery. Phenolic Compounds from Plant Sources Delivered as NanoparticlesPolyphenols are chemical structures in which there is at least one aromatic ring with a reactive hydroxyl group and they are classifi ed according to the number and the structural elements linking these rings. They can be found in several plants (mostly in leaves and fruits) and came to public attention when their capacity to fi ght reactive oxygen species (ROS) was discovered. Phenolics (including fl avonoids, anthocyanins, lignins) are secondary metabolites in plants and are important for disease resistance, tolerance to abiotic stress, and for fi ghting bacteria. Tolerance of bacteria for polyphenols depends on the type of bacterium and the structure of the polyphenol.

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“…Natural-based hydrogel like carrageenan has been chosen as the best candidate due to the unique features found in its molecular structures such as unique mechanism of gelation, ability to absorb high water content, abundant negative charges, functional groups that can be easily modified accordingly, and great chemical and proteins delivery for the tissue regeneration [6]. In fact, it is not just good for the infused material but it also has good therapeutic properties such as anticancer, antiviral, anticoagulation, and antihyperlipidaemia properties [5].…”

Section: Introductionmentioning

confidence: 99%

Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

Johari

Aizad

Zubairi

2017

International Journal of Polymer Science

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Polymeric porous 3D scaffold plays an important role in culturing mammalian cells as ex vivo model. However, the scaffold used is ineffective due to its structural and cell acceptability weaknesses. Therefore, this research attempts to overcome the weaknesses by using carrageenan from red seaweed Kappaphycus alvarezii as an alternative infused material (filler) of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) porous 3D scaffold. The 3D scaffold was conventionally fabricated using the solvent-casting particulateleaching (SCPL) method. Carrageenan was later infused into 3D porous scaffolds under vacuum pressure and freeze-drying process. Five carrageenan concentrations were prepared and its physicochemical properties such as pH and viscosity were carried out on each concentration to determine the best solutions to produce a new composite 3D structure. The preliminary result shows that carrageenan concentrations of 2, 4, and 6% (w/v) were considered the best solutions for the infusion process due to its stable rheology properties. The pH and viscosity profiles of three selected carrageenan solutions were exhibited in the range of 9.00-9.20 and 0.047-1.144 Pa⋅s, respectively. Moreover, the incorporated carrageenan gel fraction was in the range of 4.30% to 14.95% (w/w) which was determined by gravimetric analysis and dye staining method (visual assessment). The well-infused carrageenan 3D scaffold was further characterized based on its internal morphology and degradability study. The vertical cross-sections of the scaffolds revealed homogeneous accumulation of dried gelatinous carrageenan which was covered throughout its pores wall. The degradation rate ( ) of the carrageenan infused 3D scaffold was between 0.01 ± 1.66 (mg/day) and 0.03 ± 3.23 (mg/day). The higher the carrageenan concentration used, the faster the degradation rate occurring ( < 0.05). The 3D infused scaffold of 4% (w/v) carrageenan concentration (S2) produced a moderate degradation rate of 0.02 ± 1.55 (mg/day) with a sustained structural integrity up to 28 days. The carrageenan infused scaffold of 4% (w/v) was demonstrated to be the best 3D structure for a long-term cell culture (>2 weeks). In conclusion, the usage of carrageenan as a composite material exhibits its great potential to be used in tissue engineering application and 3D cell culture model.

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Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects

Cited by 261 publications

References 80 publications

Effect of seaweed on physical properties of thermoplastic sugar palm starch/agar composites

Effect of seaweed on physical properties of thermoplastic sugar palm starch/agar composites

Bionanomaterials from Plant Sources

Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

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