Review: Komposit Polimer Pektin dalam Sistem Penghantaran Obat

Lestari, Pramulani Mulya; Nining, Nining

doi:10.24198/mfarmasetika.v7i1.36568

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…Karakteristik sistem polimer yang digunakan pada DDS ini pada sistem biologis akan menimbulkan efek samping yang minimal, tidak toxic, produk degradasi yang dapat diekskresi serta tidak ada residu kimia toxic (Sagala & Nurcahyanti, 2023).…”

Section: Pendahuluanunclassified

Review Article: Pengaruh Polimer Pada Sistem Penghantaran Obat Transmukosal

Yuniarsih,

Mentari,

Susanti

et al. 2024

Buana Farma

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Currently, drug delivery systems have been widely researched and developed to enable increased bioavailability by regulating drug release. One of the factors in drug release is a composite polymer which is needed as a protective matrix for the delivery system with the aim of drug stability. One of the drug delivery targets is transmucosal. This review article aims to find out the role of various polymers in transmucosal drug delivery systems. The method used for information is the results from the ScienceDirect, PubMed, Google Scholar, ResearchGate and WoS (Web of Science) databases. The results show that CMC-Na, HPMC, chitosan, pectin, Carbopol, Acebutolol HCL, maintains the duration of the drug's residence time after the absorption process because the polymer has adhesive power.

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Section: Pendahuluanunclassified

Review Article: Pengaruh Polimer Pada Sistem Penghantaran Obat Transmukosal

Yuniarsih,

Mentari,

Susanti

et al. 2024

Buana Farma

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“…Tabel 2 dan 3, terlihat bahwa pemberian nanopartikel kitosan-ekstrak n-heksan daging buah muda kayu gadis berbeda nyata dalam penghambatan pertumbuhan 2 jenis jamur uji dimulai pada konsentrasi 0,03 dan 0,05 %. Hal ini dapat dipengaruhi oleh berbagai faktor diantaranya ukuran partikel, dan pengaruh distribusi ukuran partikel yang tidak merata serta terjadinya aglomerasi atau agregat sehingga penghambatan terhadap pertumbuhan jamur kurang signifikan (Martien et al, 2012). Dari data PSA diketahui ukuran partikel nanopartikel kitosan (basis) lebih kecil dari pada nanopartikel kitosan-ekstrak CP, dan dari data SEM juga terlihat bahwa nanopartikel yg dihasil membentuk agregat.…”

Section: Aktivitas Anti Jamurunclassified

AKTIVITAS ANTIJAMUR PELAPUK KAYU NANOPARTIKEL KITOSAN-EKSTRAK N-HEKSAN DAGING BUAH KAYU GADIS (Cinnamomum parthenoxylon)

Ekasari¹,

Nurhasana²,

Mudyanto³

et al. 2023

Biosilampari

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This study aims to synthesize chitosan nanoparticles - n-hexane extract of Cinnamomum parthenoxylon (CP) fruit using the ionic gelation method, to characterize them, and to determine their antifungal activity against the wood-rotting fungi Trametes versicolor and Fomitopsis palustris. Chitosan-CP extract nanoparticles were formulated with chitosan:Na-TPP:CP extract ratio of 1:1:0.5. Particle size and polydispersity index were determined using a particle size analyzer (PSA), and particles morphology was observed using a scanning electron microscope (SEM), and antifungal activity was measured using agar media. The results revealed that the average size of chitosan nanoparticles (base) was 276.9 nm, while the average size of chitosan-CP extract nanoparticles was 807.6 nm. The polydispersity index (PI) of both nanoparticles was greater than 0.7. Observations of the nanoparticles' morphology revealed that aggregation/agglomeration formed in the resulting particles. Both nanoparticles chitosan (base) and chitosan-CP extract inhibited the growth of white rot fungi (T. versicolor) more than brown rot fungi (F. palustris), as measured by the inhibitory zone.

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“…(2002) flavonoid menurunkan glukosa darah dengan menghambat kerja protein transporter gula dalam membran usus, sehingga menyebabkan kadar glukosa darah akan turun. Selain itu, flavonoid juga mampu meregenerasi sel β-pankreas dengan cara meningkatkan aktifitas enzim antioksidan, sehingga dapat mengatasi defisiensi insulin (Martien et al, 2012).…”

Section: Penurunan Kadar Glukosa Darahunclassified

ANALYSIS OF THE ABILITY OF NANO ETHANOL EXTRACT OF CORIANDER (Coriandrum sativum L.) SEEDS TO REDUCE BLOOD GLUCOSE LEVELS IN HYPERGLYCEMIC WISTAR RATS

Wahjuni,

Parwata,

Putra

et al. 2023

J. IPI

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Nano ethanol extract of coriander seeds is proven to increase the activity of active compounds in the body. This research was conducted to see the ability of coriander seed ethanol extract to reduce glucose levels in hyperglycemic rats compared to coriander seed extract without nano. The size of the nano coriander seed extract after being characterized by the Particle Size Analyzer (PSA) was 182.4 nm and the zeta potential value was -1.5 mV. The activity test results showed the ability of the coriander seed ethanol extract to be more effective in lowering blood glucose levels compared to the coriander seed extract without nano. Identification of compounds thought to be effective as hypoglycemics using Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS), identified 7 compounds namely phenylalanine, indole, apigenin, 4-methoxybenzaldehyde, 2,5-dimethoxybenzaldehyde, 2-flouren-9-ylidenemethyl-pyridine , and 5-pentyl-1,3-benzenediol, which are suspected to be active as hypoglycemics are phenylalanine, indole, apigenin, and 2,5-dimethoxybenzaldehyde. The ethanol extract of coriander seeds in nanoparticle preparations is more effective in reducing blood glucose levels than the ethanol extract of coriander seeds without nano preparations

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Review: Komposit Polimer Pektin dalam Sistem Penghantaran Obat

Cited by 3 publications

References 55 publications

Review Article: Pengaruh Polimer Pada Sistem Penghantaran Obat Transmukosal

Review Article: Pengaruh Polimer Pada Sistem Penghantaran Obat Transmukosal

AKTIVITAS ANTIJAMUR PELAPUK KAYU NANOPARTIKEL KITOSAN-EKSTRAK N-HEKSAN DAGING BUAH KAYU GADIS (Cinnamomum parthenoxylon)

ANALYSIS OF THE ABILITY OF NANO ETHANOL EXTRACT OF CORIANDER (Coriandrum sativum L.) SEEDS TO REDUCE BLOOD GLUCOSE LEVELS IN HYPERGLYCEMIC WISTAR RATS

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