Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Abstract

Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

Remote-Controllable Bone-Targeted Delivery of Estradiol For the Treatment of Ovariectomy-Induced Osteoporosis in Rats

“…These results confirmed that temperature played a critical role in drug release, and the amount of drug released increased at higher temperatures, which was consistent with other carrier systems reported before [24]. Employing an appropriate vector is an important issue in developing a bone-targeting delivery system [40]. Based on the above information, the co-loaded NPs could be an extremely promising method of bone-targeted delivery.…”

Ultrathin 2D Inorganic Ancient Pigment Decorated 3D‐Printing Scaffold Enables Photonic Hyperthermia of Osteosarcoma in NIR‐II Biowindow and Concurrently Augments Bone Regeneration

“…[ 2 ] Besides, the critical bone defects after surgery, drug‐resistance and side effects also attenuate the therapeutic effects and induce poor prognosis. [ 3 , 4 ] Notably, except for the elimination of tumor tissues, reconstruction of the critical bone defects afterward was also unsatisfactory currently and challenging. [ 3 , 5 , 6 ] Hence, more efficient and advanced platforms are instantly needed to be developed for achieving both effective OS elimination and enhanced bone regeneration.…”

Self-Assembly Engineering Nanodrugs Composed of Paclitaxel and Curcumin for the Combined Treatment of Triple Negative Breast Cancer

“…Significant work has been dedicated to developing drug delivery system that can concurrently deliver PTX and Cur to the tumor site, which might provide improved therapeutic activity and safety. However, most reported carriers have limited loading capacity and there are also concerns regarding their possible toxicity and biodegradation (Hiremath et al, 2019;Li et al, 2019;Zhao et al, 2019;Shao et al, 2020;Xiong et al, 2020;Hu et al, 2021;Liao et al, 2021;Zhang et al, 2021). Carrierfree drug delivery systems are recently developed alternatives that do not rely on inert carriers and thus avoid potential toxicity.…”