Reinforced concrete pile foundations are a common and efficient solution for constructing deepwater bridges that span large bodies of water, such as rivers, seas, or portions of oceans. Many of these bridges are situated in areas with significant seismic hazards. These structures are not only subjected to typical water loads, such as currents and waves but also to earthquake forces. The interaction between these water forces and the structure generates hydrodynamic forces on the submerged parts of the bridges. Thus, accurately estimating these hydrodynamic forces during earthquakes is crucial for ensuring the structural safety of deepwater bridges. This chapter aims to assess the structural response of pile foundation bridge piers when exposed to hydrodynamic forces during earthquakes, utilizing DIANA FE software and parallel computation technology. The study model incorporates the combined effects of currents, waves, and earthquakes, along with the nonlinear behavior of soil and concrete. Using Stokes’s fifth-order wave theory and Morison’s hydrodynamic pressure formula, the wave force was applied as a distributed load on the bridge’s pile foundation. The dynamic excitation characteristics of the pier under elastic conditions were analyzed, considering the influence of currents and waves.