Review of advances in electrospinning-based strategies for spinal cord regeneration

Li, Yiran; Dong, Ting; Li, Zhiwei; Ni, Shilei; Zhou, Fang; Alimi, Olawale Alimi; Chen, Shaojuan; Duan, Bin; Kuss, Mitchell; Wu, Shaohua

doi:10.1016/j.mtchem.2022.100944

Cited by 65 publications

(53 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is popular due to its simple device, low cost, and controllable process [ 25 , 26 ]. Porous nanofiber prepared by electrospinning have the advantages of high specific surface area, high porosity, and high adsorption [ 27 ]. It is widely used in filtration, sensors, and adsorption [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Yang

Lu³

et al. 2022

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Crude oil spills seriously harm the ocean environment and endanger the health of various animals and plants. In the present study, a totally biodegradable polymer, poly(L-lactic acid) (PLLA), was employed to fabricate highly porous oil absorbent nanofibrous materials by using a combination of electrospinning technique and subsequent acetone treatment. We systematically investigated how the electrospinning parameters affected formation of the porous structure of PLLA nanofibers and demonstrated that PLLA nanofibers with decreased and uniform diameter and improved porosity could be rapidly prepared by adjusting solution parameters and spinning parameters. We also demonstrated that the acetone treatment could obviously enhance the pore diameter and specific surface area of as-optimized electrospun PLLA nanofibers. The acetone treatment could also improve the hydrophobic property of as-treated PLLA nanofiber membranes. All these led to a significant increase in oil absorption performance. Through our research, it was found that the oil absorption of PLLA nanofiber membrane increased by more than double after being treated with acetone and the oil retention rate was also improved slightly.

show abstract

Section: Introductionmentioning

confidence: 99%

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Yang

Lu³

et al. 2022

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many existing studies have demonstrated that the electrospinning nanofibers could promote cell attachment, the proliferation of human dermal fibroblasts in vitro, and the acceleration of wound healing and skin regeneration in vivo [ 14 ]. Importantly, electrospinning-based nanofibers are always collected into nonwoven mat-like structure, which has been demonstrated to possess great air and moisture permeability, as well as excellent pathogen barrier properties [ 15 ]. Therefore, electrospun nanofibrous mats are assuredly ideal candidates as wound dressing materials.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing

Zhao

et al. 2022

Nanomaterials

Self Cite

View full text Add to dashboard Cite

The design and development of novel dressing materials are urgently required for the treatment of chronic wounds caused by diabetic ulcers in clinics. In this study, ursolic acid (UA) extracted from Chinese herbal plants was encapsulated into electrospun nanofibers made from a blend of chitosan (CS) and polyvinyl alcohol (PVA) to generate innovative CS-PVA-UA dressings for diabetic wound treatment. The as-prepared CS-PVA-UA nanofiber mats exhibited randomly aligned fiber morphology with the mean fiber diameters in the range of 100–200 nm, possessing great morphological resemblance to the collagen fibrils which exist in the native skin extracellular matrix (ECM). In addition, the CS-PVA-UA nanofiber mats were found to possess good surface hydrophilicity and wettability, and sustained UA release behavior. The in vitro biological tests showed that the high concentration of UA could lead to slight cytotoxicity. It was also found that the CS-PVA-UA nanofiber dressings could significantly reduce the M1 phenotypic transition of macrophages that was even stimulated by lipopolysaccharide (LPS) and could effectively restore the M2 polarization of macrophages to shorten the inflammatory period. Moreover, the appropriate introduction of UA into CS-PVA nanofibers decreased the release levels of TNF-α and IL-6 inflammatory factors, and suppressed oxidative stress responses by reducing the generation of reactive oxygen species (ROS) as well. The results from mouse hepatic hemorrhage displayed that CS-PVA-UA nanofiber dressing possessed excellent hemostatic performance. The in vivo animal experiments displayed that the CS-PVA-UA nanofiber dressing could improve the closure rate, and also promote the revascularization and re-epithelization, as well as the deposition and remodeling of collagen matrix and the regeneration of hair follicles for diabetic wounds. Specifically, the mean contraction rate of diabetic wounds using CS-PVA-UA nanofiber dressing could reach 99.8% after 18 days of treatment. In summary, our present study offers a promising nanofibrous dressing candidate with multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis functions, for the treatment of hard-to-heal diabetic wounds.

show abstract

“…Electrospinning with a few minor improvisations has been used to prepare advanced materials. For instance, in the fabrication of lithium‐sulfur batteries (Y. Zhang et al, 2022), lithium‐ion batteries (Joshi et al, 2022), spinal cord regeneration (Y. Li et al, 2022), waterproof, breathable textiles (Zhou et al, 2022), etc. It is noteworthy to mention that nanofibers fabricated with electrospinning have diverse potential applications in many aspects, like templates, reinforcement, filtration, catalysis, pharmaceutical applications, electronic and optical device manufacture (Choi et al, 2009; Jiang et al, 2018; S. Li et al, 2019; Z. Liu et al, 2018; P. Lu et al, 2018; Palazzetti & Zucchelli, 2017; Qin & Wang, 2008; Sundarrajan et al, 2014; Zafar et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Recent trends using natural polymeric nanofibers as supports for enzyme immobilization and catalysis

Khan

Rather

Wani

et al. 2022

Biotech & Bioengineering

View full text Add to dashboard Cite

All the disciplines of science, especially biotechnology, have given continuous attention to the area of enzyme immobilization. However, the structural support made by material science intervention determines the performance of immobilized enzymes. Studies have proven that nanostructured supports can maintain better catalytic performance and improve immobilization efficiency. The recent trends in the application of nanofibers using natural polymers for enzyme immobilization have been addressed in this review article. A comprehensive survey about the immobilization strategies and their characteristics are highlighted. The natural polymers, e.g., chitin, chitosan, silk fibroin, gelatin, cellulose, and their blends with other synthetic polymers capable of immobilizing enzymes in their 1D nanofibrous form, are discussed. The multiple applications of enzymes immobilized on nanofibers in biocatalysis, biosensors, biofuels, antifouling, regenerative medicine, biomolecule degradation, etc.; some of these are discussed in this review article.

show abstract

Review of advances in electrospinning-based strategies for spinal cord regeneration

Cited by 65 publications

References 188 publications

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Electrospun Biodegradable Poly(L-lactic acid) Nanofiber Membranes as Highly Porous Oil Sorbent Nanomaterials

Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing

Recent trends using natural polymeric nanofibers as supports for enzyme immobilization and catalysis

Contact Info

Product

Resources

About