Review of allergic contact dermatitis: Scratching the surface

Weintraub, Gil; Lai, Isabella N.; Kim, Christina N.

doi:10.5314/wjd.v4.i2.95

Cited by 4 publications

(4 citation statements)

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“…The EC (2020) has therefore issued a list of the 25 most allergic compounds, among which are several components of essential oils. The most common symptoms of allergic contact dermatitis caused by an allergen present in EOs are itching, redness and fl aking, which usually occur at the site of contact with the EO but may extend beyond this area (Weintraub et al, 2015;Sarkic and Stappen, 2018).…”

Section: Components Of Four Most Interesting Essential Oilsmentioning

confidence: 99%

Ceylon cinnamon and clove essential oils as promising free radical scavengers for skin care products

Martiniaková

Ácsová

Hojerová

et al. 2022

Acta Chimica Slovaca

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Due to adverse effects of free radicals on human skin and increasing consumer demand for natural ingredients, essential oils from basil, Ceylon cinnamon bark, clove, juniper, lavender, oregano, rosemary, tea tree, thyme, and ylang-ylang were assessed for their antiradical activity. The oils were evaluated in the concentration range of 5—0.1 mg·mL−1, in which the three reference synthetic antioxidants are most often added to mass-produced cosmetics. Among all examined samples, C. cinnamon oil at a concentration of 5 mg·mL−1 showed the strongest DPPH radical scavenging activity (0.41 mg·mL−1 IC50), followed by clove oil, BHA, α-tocopherol, and BHT (0.82, 0.84, 0.88 and 0.93 mg·mL−1 IC50), respectively. At the same concentration, the reduction power of C. cinnamon oil was higher (1.64 mg·mL−1 Trolox Eq.) than that of α-tocopherol and BHT (1.42 and 0.80 mmol·L−1 Trolox Eq., respectively) but lower than that of BHA (1.81 mmol·L–1 Trolox Eq.). Antiradical activity of the other eight essential oils was low or negligible. C. cinnamon oil and clove oil are promising antiradical agents for skin care but according to our GC-MS analysis, these oils contain 0.29 % of cinnamaldehyde, 0.03 % of linalool, 0.02 % of D-limonene, and 0.02 % of eugenol or 0.41 % of eugenol and 0.002 % of linalool, respectively, which are monitored contact allergens in cosmetics. Such a product is not be suitable for consumers allergic to these substances but for the vast majority of consumers it does not pose a risk in terms of allergic manifestations.

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Section: Components Of Four Most Interesting Essential Oilsmentioning

confidence: 99%

Ceylon cinnamon and clove essential oils as promising free radical scavengers for skin care products

Martiniaková

Ácsová

Hojerová

et al. 2022

Acta Chimica Slovaca

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“…As the main purpose of identifying and reporting OD is prevention (13), it is clear that not reporting occupational dermatoses hinders the implementation of prevention programmes with an immense impact on both the costs related to these illnesses and an increase in absenteeism and presenteeism in Eastern European countries, leading to a significant economic burden as mentioned by Weintraub et al …”

Section: Discussionmentioning

confidence: 99%

The Eastern European experience on occupational skin diseases. Make underreporting an issue?

Moldovan

Voidăzan

John

et al. 2017

Acad Dermatol Venereol

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The most valuable method for a proper recognition of OSD is to increase the awareness of physicians involved in the management of OSD (occupational physicians, GPs, dermatologists), as well as employers and workers. There is an urgent need to improve national legislation, to develop and promote adequate preventive programmes, emphasizing ethical, legal, economical and psychological aspects in order to achieve an increased recognition and a real reporting of OSD, and to enforce an international action plan for Eastern Europe in order to improve the notification of OSD.

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“…A role for P2X7 in ACD in humans is supported by the up-regulation of this receptor in the epidermal basal layer of inflamed skin of atopic dermatitis patients compared to normal human skin [88] , while other experimental evidence supports a role for P2X7 in murine models of ACD. ACD is commonly studied using animal models of contact hypersensitivity (CHS) [87] . Both pharmacological blockade and genetic deficiency of P2X7 impairs CHS responses in mice [89] .…”

Section: Allergic Contact Dermatitismentioning

confidence: 99%

“…Allergic contact dermatitis (ACD) is a type IV delayedtype hypersensitivity (DTH) reaction characterised by a T cell-mediated response to allergens [87] . A role for P2X7 in ACD in humans is supported by the up-regulation of this receptor in the epidermal basal layer of inflamed skin of atopic dermatitis patients compared to normal human skin [88] , while other experimental evidence supports a role for P2X7 in murine models of ACD.…”

Section: Allergic Contact Dermatitismentioning

confidence: 99%

P2X7 receptor in skin biology and diseases

Geraghty¹,

Watson²,

Adhikary³

et al. 2016

WJD

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The P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. AbstractThe P2X7 receptor is a trimeric ligand-gated cation channel present on immune and other cells. Activation of this receptor by its natural ligand extracellular adenosine triphosphate results in a variety of downstream responses, including the release of pro-inflammatory mediators and cell death. In normal skin, P2X7 is present on keratinocytes, Langerhans cells and fibroblasts, while the presence of this receptor on other cutaneous cells is mainly inferred from studies of equivalent cell types present in other tissues. Mast cells in normal skin however express negligible amounts of P2X7, which can be upregulated in cutaneous disease. This review discusses the potential significance of P2X7 in skin biology, and the role of this receptor in inflammatory skin disorders such as irritant and chronic dermatitis, psoriasis, graft-versus-host disease, as well is in wound healing, transplantation and skin cancer. Core tip: The P2X7 receptor is present on immune, stromal and epithelial cells. Activation of this receptor by its natural ligand, extracellular adenosine triphosphate, causes a variety of downstream effects including release of inflammatory mediators and growth factors, as well as cell death. P2X7 has various functions on skin cells, and studies of mouse models of disease and of human cells and tissues highlight emerging roles for this receptor in common skin disorders.

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Review of allergic contact dermatitis: Scratching the surface

Cited by 4 publications

References 0 publications

Ceylon cinnamon and clove essential oils as promising free radical scavengers for skin care products

Ceylon cinnamon and clove essential oils as promising free radical scavengers for skin care products

The Eastern European experience on occupational skin diseases. Make underreporting an issue?

P2X7 receptor in skin biology and diseases

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