Review of Anti-Bacterial Activities of Curcumin against Pseudomonas aeruginosa

Neyestani, Zohreh; Ebrahimi, Seyed Ali; Ghazaghi, Anahita; Jalili, Amin; Sahebkar, Amirhossein; Rahimi, Hamid Reza

doi:10.1615/critreveukaryotgeneexpr.2019029088

Cited by 18 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous literature has reported that turmeric has an antimicrobial (antibacterial and antifungal) effect [ 49 , 140 , 141 , 142 ]. Curcumin is known for its inhibitory action on microorganisms such as E. coli, S. aureus, Salmonella typhimurium , and Pseudomonas aeruginosa [ 141 , 143 ]. In numerous literature works, turmeric’s extracts have been shown to have strong antioxidant properties.…”

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

show abstract

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Apart from this, Curcumin is well known for its antibacterial and antifungal property for which it is widely used in traditional medicinal practices in India, China, and in other south-Asian countries. There are plentiful reports suggesting this wonder phytochemical to even serve as QSA which has been proved in P. aeruginosa, C. albicans, Aeromonas hydrophila 4,[67][68][69] .…”

Section: Discussionmentioning

confidence: 99%

Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition

Shukla

Parmar

et al. 2021

Sci Rep

View full text Add to dashboard Cite

There persists a constant threat from multidrug resistance being acquired by all human pathogens that challenges the well-being of humans. This phenomenon is predominantly led by Pseudomonas aeruginosa which is already resistant to the current generations of antibiotic by altering its metabolic pathways to survive. Specifically for this microbe the phenomenon of quorum sensing (QS) plays a crucial role in acquiring virulence and pathogenicity. QS is simply the cross talk between the bacterial community driven by signals that bind to receptors, enabling the entire bacterial microcosm to function as a single unit which has led to control P. aeruginosa cumbersome even in presence of antibiotics. Inhibition of QS can, therefore, be of a significant importance to curb such virulent and pathogenic strains of P. aeruginosa. Natural compounds are well known for their antimicrobial properties, of which, information on their mode of action is scarce. There can be many antimicrobial phytochemicals that act by hindering QS-pathways. The rationale of the current study is to identify such natural compounds that can inhibit QS in P. aeruginosa driven by LasR, PhzR, and RhlR dependent pathways. To achieve this rationale, in silico studies were first performed to identify such natural compounds which were then validated by in vitro experiments. Gingerol and Curcumin were identified as QS-antagonists (QSA) which could further suppress the production of biofilm, EPS, pyocyanin, and rhamnolipid along with improving the susceptibility to antibiotics.

show abstract

“…Furthermore, its adaptive antibiotic resistance mechanisms enable recurrent infections. Therefore, alternative therapies for P. aeruginosa infections prevention and treatment are needed [127,128]. To achieve this, Samrot et al [129] produced CS/Cur NPs smaller than 50 nm, which exhibited in vitro prolonged release and antibacterial activity against P. aeruginosa.…”

Section: Cs Nanoparticles For Curcumin Deliverymentioning

confidence: 99%

Chitosan Nanoparticles Potentiate the in vitro and in vivo Effects of Curcumin and other Natural Compounds

Lopes

Giongo

Campos

et al. 2021

CMC

View full text Add to dashboard Cite

: The development of biodegradable nanoparticles is an important tool for the biological transport of chemical compounds. The nanoencapsulation reduces the biopharmaceutical and pharmacokinetic drawbacks of compounds and enhances their biological properties. Naturally occurring polymers such as proteins and polysaccharides have been widely applied in the development of nanostructured systems of several therapeutic agents. Among them is chitosan, a crustaceancarapace-chitin derived biopolymer. In addition to its biocompatibility and biodegradability, chitosan is known for its mucoadhesion properties. Chitosan-based nanostructured systems potentiate most of aspects of the loaded drugs, including cellular transport and other biological effects. The use of chitosan nanoparticles enhances permeation, stability, and bioactivity of natural compounds. In this review, an overview of the main features of chitosan nanoparticles that improved in vitro and in vivo effects of bioactive natural molecules is given, emphasizing the results obtained with curcumin.

show abstract

Review of Anti-Bacterial Activities of Curcumin against Pseudomonas aeruginosa

Cited by 18 publications

References 0 publications

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition

Chitosan Nanoparticles Potentiate the in vitro and in vivo Effects of Curcumin and other Natural Compounds

Contact Info

Product

Resources

About