Review of antibacterial and antifungal activity of 1,2,4-triazole derivatives

Samura, Т. О.

doi:10.32352/0367-3057.5.15.02

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…The action's mechanism: antimitotic agent, because it can interfere with fungal cell division and mitosis, griseofulvin is categorized as an antimitotic agent. It prevents the formation of the mitotic spindle required for fungal cell division by interfering with the assembly of microtubules [15]. 3.…”

Section: Nature and Classi Cation Of Griseofulvinmentioning

confidence: 99%

Investigating the Propagating effects of Griseofulvin on Erectile Dysfunction: A Comprehensive Computational and Molecular Docking Study on Human Phosphodiesterase 5 proteins (1UDT and 1UDU).

Shinggu,

Etim,

Humphrey

et al. 2024

Preprint

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Erectile dysfunction (ED) is a prevalent condition affecting a significant portion of the male population. This research delves into the potential link between Griseofulvin, a known antifungal medication, and its impact on erectile function. A comprehensive computational approach was employed. Optimization of griseofulvin was carried out using the highly reputable density functional theory (DFT) with the B3LYP functional and 6–31*G(d,p) using water and ethanol as the solvents of interest. We explored the interactions of Griseofulvin with Human Phosphodiesterase 5 proteins (PDE5), specifically targeting the crystal structures 1UDT and 1UDU. Molecular docking studies provided valuable insights into the binding mechanisms of Griseofulvin with PDE5, shedding light on potential allosteric modulation and conformational changes. Further molecular docking studies were carried out on other popular antifungal drugs like amphotericin, terbinafine and ketoconazole in order to compare their interactions with 1UDT and 1UDU with that of griseofulvin. Through an array of computational analyses, including molecular dynamics simulations and binding free energy calculations, we aimed to elucidate the propagating effects of Griseofulvin on the catalytic activity and structural stability of PDE5. The findings from this research could contribute to a deeper understanding of the molecular mechanisms underlying Griseofulvin's impact on erectile function, potentially opening avenues for the development of novel therapeutic interventions for ED.

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Section: Nature and Classi Cation Of Griseofulvinmentioning

confidence: 99%

Investigating the Propagating effects of Griseofulvin on Erectile Dysfunction: A Comprehensive Computational and Molecular Docking Study on Human Phosphodiesterase 5 proteins (1UDT and 1UDU).

Shinggu,

Etim,

Humphrey

et al. 2024

Preprint

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Novel 1, 2, 4-Triazoles as Antifungal Agents

Kazeminejad

Marzi

Shiroudi

et al. 2022

BioMed Research International

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The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity.

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Review of antibacterial and antifungal activity of 1,2,4-triazole derivatives

Cited by 2 publications

References 16 publications

Investigating the Propagating effects of Griseofulvin on Erectile Dysfunction: A Comprehensive Computational and Molecular Docking Study on Human Phosphodiesterase 5 proteins (1UDT and 1UDU).

Investigating the Propagating effects of Griseofulvin on Erectile Dysfunction: A Comprehensive Computational and Molecular Docking Study on Human Phosphodiesterase 5 proteins (1UDT and 1UDU).

Novel 1, 2, 4-Triazoles as Antifungal Agents

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