Review of antibiotic use and resistance in food animal production in WHO South-East Asia Region

Malik, Hina; Singh, Randhir; Kaur, Simranpreet; Dhaka, Pankaj; Bedi, Jasbir Singh; Gill, J.P.S.; Gongal, Gyanendra.

doi:10.1016/j.jiph.2023.11.002

Cited by 10 publications

(4 citation statements)

References 72 publications

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“…Enrofloxacin (ENR), a synthetic fluoroquinolone antibiotic, is classified as an animal-specific drug and is widely used to control diseases in aquatic organisms [ 7 , 8 ]. However, the widespread use of antibiotics has led to the problem of bacterial resistance [ 9 , 10 ], which caused aquatic animals to exhibit symptoms such as immune system damage, physiological abnormalities, and gut flora dysbiosis [ 11 , 12 ]. Furthermore, human health and environmental ecology would be affected along with the enrichment effect in organisms [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Enrofloxacin Rapid Detection in Aquatic Foods: Based on DNA Aptamer Sensor

Bao,

Wang,

Hao

et al. 2024

Foods

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Enrofloxacin (ENR) is widely used as a synthetic fluoroquinolone antibiotic for disease control in aquatic animals. ENR aptamers were screened in this study using the magnetic bead-SELEX method, and a graphene oxide fluorescent sensor was developed to detect the ENR residues in aquatic products. Firstly, ENR was conjugated to amino magnetic beads by amidation reaction, and then the aptamer sequences showing high affinity to ENR were screened step by step by using the SELEX screening method. Finally, after 10 rounds of SELEX screening, six candidate aptamers with high affinity were obtained. Among these, ENR-Apt 6 was selected based on its secondary structure features, high affinity (Kd = 35.08 nM), and high specificity to ENR. Furthermore, a fluorescent sensor was prepared using graphene oxide and ENR-Apt 6. The results showed that the linear range of the sensor could reach 600 nM (R2 = 0.986), while its optimal linear range was 1–400 nM (R2 = 0.991), with the lowest detection limit of 14.72 nM. The prepared sensor was successfully used for the detection of ENR in real samples, with a recovery range of 83.676–114.992% and a relative standard deviation < 10% for most of the samples.

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Section: Introductionmentioning

confidence: 99%

Enrofloxacin Rapid Detection in Aquatic Foods: Based on DNA Aptamer Sensor

Bao,

Wang,

Hao

et al. 2024

Foods

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“…Antibiotics in food animals are not limited to therapeutic use, but also used for metaphylaxis (administration to animals when perceived to be in contact with animals diagnosed with disease), for prophylaxis (administration of antimicrobials to animals to prevent disease) and as growth promoters to boost feed efficiency and increase weight gain [ 5 , 6 ]. Antibiotics such as colistin, tetracycline, doxycycline, and ciprofloxacin, which are critical to human health, are commonly used for growth promotion in poultry in developing countries [ [7] , [8] , [9] , [10] ]. Antibiotic use as growth promoters is increasing in developing countries due to the rising population and an escalated demand for animal products [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and practices related to antibiotics among poultry producers and veterinarians in two Indian states

Sharma,

Dey,

Hazarika

et al. 2024

One Health

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“…Although diet has also been optimized for sustainability in terms of growth rate and feed efficiency, the effect of diet on the composition of the intestinal microbiota has not been fully explored. Namely, the composition of the broiler jejunal microbiota and the potential diet-induced effects thereof are currently unknown, which is of specific interest as it is one of the principal sites of nutrient absorption [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The relevance of intestinal microbiota alteration was first highlighted when growth promoters in the form of antibiotics were established to affect the microbiota and increase performance and feed efficiency of chickens [11][12][13][14]. However, this sub-therapeutic use of antibiotics has the added effect to enrich for antibiotic resistant bacteria, leading to its prohibition in regions such as Europe, the United States, and parts of Asia [15][16][17][18][19][20][21]. As a result, previous studies have investigated the impact of diet composition and additives on the intestinal microbiota in search for alternatives to mimic antibioticdriven beneficial effects, such as enhanced performance and feed efficiency [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium

Stege,

Schokker,

Harders

et al. 2024

BMC Genomics

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Modern broiler breeds allow for high feed efficiency and rapid growth, which come at a cost of increased susceptibility to pathogens and disease. Broiler growth rate, feed efficiency, and health are affected by the composition of the gut microbiota, which in turn is influenced by diet. In this study, we therefore assessed how diet composition can affect the broiler jejunal gut microbiota. A total of 96 broiler chickens were divided into four diet groups: control, coated butyrate supplementation, medium-chain fatty acid supplementation, or a high-fibre low-protein content. Diet groups were sub-divided into age groups (4, 12 and 33 days of age) resulting in groups of 8 broilers per diet per age. The jejunum content was used for metagenomic shotgun sequencing to determine the microbiota taxonomic composition at species level. The composed diets resulted in a total of 104 differentially abundant bacterial species. Most notably were the butyrate-induced changes in the jejunal microbiota of broilers 4 days post-hatch, resulting in the reduced relative abundance of mainly Enterococcus faecium (-1.8 l2fc, Padj = 9.9E-05) and the opportunistic pathogen Enterococcus hirae (-2.9 l2fc, Padj = 2.7E-08), when compared to the control diet. This effect takes place during early broiler development, which is critical for broiler health, thus exemplifying the importance of how diet can influence the microbiota composition in relation to broiler health. Future studies should therefore elucidate how diet can be used to promote a beneficial microbiota in the early stages of broiler development.

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Review of antibiotic use and resistance in food animal production in WHO South-East Asia Region

Cited by 10 publications

References 72 publications

Enrofloxacin Rapid Detection in Aquatic Foods: Based on DNA Aptamer Sensor

Enrofloxacin Rapid Detection in Aquatic Foods: Based on DNA Aptamer Sensor

Knowledge and practices related to antibiotics among poultry producers and veterinarians in two Indian states

Diet-induced changes in the jejunal microbiota of developing broilers reduce the abundance of Enterococcus hirae and Enterococcus faecium

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