Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors

Wang, Le; Zhang, Yanming; Du, Xia; Ding, Teng; Gong, Weiling; Liu, Feng

doi:10.1016/j.biopha.2019.109408

Cited by 21 publications

(12 citation statements)

References 98 publications

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“…At present, the exact pathophysiological mechanism of depression is still elusive, various hypotheses have been proposed to explain this disease, including monoamine neurotransmitter disturbance, hypothalamic/pituitary/adrenal (HPA) axis disorder, neurotrophic factor deficiency, and immune dysfunction ( 5 , 6 ). Increasing evidence shows that classic antidepressants targeting serotonergic neurons may be ineffective in a considerable part of patients ( 7 ). Thus, the specific therapeutic strategies are required to be developed for the treatment of MDD.…”

Section: Introductionmentioning

confidence: 99%

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Li¹,

Sun²,

Song³

et al. 2021

JCI Insight

144

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Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed cell death depending on Caspase–gasdermin D (Casp-GSDMD), which is involved in multiple neuropsychiatric diseases. However, the involvement of pyroptosis in the onset of MDD and glial pathological injury remains obscure. Here, we observed that depressive mice showed astrocytic pyroptosis, which was responsible for astrocyte loss, and selective serotonin reuptake inhibitor (SSRI) treatment could attenuate the pyroptosis induced by the chronic mild stress (CMS) model. Genetic KO of GSDMD, Casp-1, and astrocytic NOD-like receptor protein 3 (NLRP3) inflammasome in mice alleviated depression-like behaviors and inhibited the pyroptosis-associated protein expression. In contrast, overexpression of astrocytic GSDMD–N-terminal domain (GSDMD-N) in the hippocampus could abolish the improvement of behavioral alterations in GSDMD-deficient mice. This work illustrates that targeting the NLRP3/Casp-1/GSDMD–mediated pyroptosis may provide potential therapeutic benefits to stress-related astrocyte loss in the pathogenesis of depression.

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Section: Introductionmentioning

confidence: 99%

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Li¹,

Sun²,

Song³

et al. 2021

JCI Insight

144

View full text Add to dashboard Cite

show abstract

“…Effective management of obesity and its associated emotional complications is a challenging task unless underlying neurobiological mechanisms are fully understood 32,33 . In this study, mice were fed either a high-fat diet or a normal diet for 17 weeks, and since the serotonin system is a major factor in mood regulation 34 , therefore, at 3, 5, 11, 17 weeks, ethology and 5-HT neuroenergy analysis were carried out to determine the relationship between the high-fat diet and the serotonin system. Recent studies have shown that some 5-HT receptor subtypes, of which 5-HT 1A , play an important role in anxiety and depression relief 34 .…”

Section: Discussionmentioning

confidence: 99%

“…In this study, mice were fed either a high-fat diet or a normal diet for 17 weeks, and since the serotonin system is a major factor in mood regulation 34 , therefore, at 3, 5, 11, 17 weeks, ethology and 5-HT neuroenergy analysis were carried out to determine the relationship between the high-fat diet and the serotonin system. Recent studies have shown that some 5-HT receptor subtypes, of which 5-HT 1A , play an important role in anxiety and depression relief 34 . Glucose preference test, open eld test, forced swimming, tail suspension test and pathological observation were used to determine depression-like features and hippocampal injury, and 5-HT content in brain was assessed by ELISA Kit.…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes of serotonin levels induces depression-like behaviour in mice with high-fat diet

Chen

Gong

et al. 2021

Preprint

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Introduction of SSRI as the first-line pharmacotherapy options for depression, which purpose is to increase the concentrations of 5-HT in brain and help reduce depressive symptoms. However, there are still many limitations to the effectiveness of these treatment strategies, 30-40% of patients do not respond to treatment at all, and even suicide occurs. In the present study, we revealed that increasing brain 5-HT concentration is not the best treatment options. When we injected sufficient amounts of 5-HT into the lateral ventricular region of mice, it actually caused depression-like behavior in the animals. The second study on high-fat fed induces depressive symptoms in mice demonstrated that 5-HT concentration in brain showed a tendency to increase first and then decrease. Both experiments indicated that if SSRI are administrated to the patient in the acute phases of depression, it may lead to exacerbation of mental disorders or suicidal tendencies.

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“…Piperazine derivatives belong to the basic chemical structures for the preparation of new compounds acting on the serotoninergic system [ 9 ]. Many studies have described the structure-activity relationship of large numbers of compounds with a chemical structure to the arylpiperazine side chain [ 9 , 51 ]. The attempts are still being made to develop metabolically stable derivatives as drug candidates [ 52 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of LC-MS and LC-DAD Methods of Detecting Abused Piperazine Designer Drugs

Welz

Koba

Kośliński

et al. 2022

JCM

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Recreational use of piperazine designer drugs is a serious threat to human health. These compounds act on the body in a similar fashion to illegal drugs. They induce psychostimulatory effects as well as visual and auditory hallucinations to varying degrees. In many cases of poisoning and deaths, the presence of two or even several psychoactive substances have been demonstrated. Piperazine derivatives are often found in such mixtures and pose a great analytical problem during their identification. Additionally, some piperazine derivatives can be detected in biological material as a result of metabolic changes to related drugs. Therefore, it is necessary to correctly identify these compounds and ensure repeatability of determinations. This article presents a comparison of the methods used to detect abused piperazine designer drugs using liquid chromatography in combination with a diode-array detector (LC-DAD) or mass spectrometer (LC-MS). Each of methods can be used independently for determinations, obtaining reliable results in a short time of analysis. These methods can also complement each other, providing qualitative and quantitative confirmation of results. The proposed methods provide analytical confirmation of poisoning and may be helpful in toxicological diagnostics.

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Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors

Cited by 21 publications

References 98 publications

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Dynamic changes of serotonin levels induces depression-like behaviour in mice with high-fat diet

Comparison of LC-MS and LC-DAD Methods of Detecting Abused Piperazine Designer Drugs

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