Review of Application of Tissue Nano transfection for Vascular Injuries and Traumas

Abstract

With vascular surgeons involved in increasing numbers of lower extremity arterial traumas, vascular injuries are a prevalent problem in today’s society [16]. Vascular injuries are often causes of vascular diseases such as atherosclerosis and are separated into three categories: blunt, penetration, or a combination of the two.[1] These injuries can often lead to symptoms such as bleeding, swelling, lumps on the skin, and bruising. Tissue Nano Transfection (TNT) is a novel technology that uses nanotechnology-based chip hardware to deliver specific genes to reprogram one tissue type into another. TNT can improve vasculature by repairing damaged tissues. TNT has the benefits of not requiring laboratory-based procedures, quick treatment, and minimal invasiveness. However, the status quo of TNT calls for commercial, clinical, and biological needs, all of which are discussed in this paper. Although relatively novel, tissue nano-transfection, combined with practicality, could be used worldwide to help patients not only as a vascular injury treatment but also as a revolutionary form of cell therapy. All things considered, TNT has had numerous successes through non-viral gene delivery, an advantage over many current forms of cell therapy due to complications of doing viral gene delivery.