Review of Atypical Organometallic Compounds as Antimalarial Drugs

Abstract

Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.

Synthesis and in vitro Antibacterial Evaluation of N‐(4‐methoxy‐2‐nitrophenyl)‐β‐alanine Derivatives

“…In recent decades, the number of antibacterial agents has decreased and has not met the challenges of treating multidrug‐resistant pathogens [1,2] . Resistance to a last‐resort antibiotics, namely vancomycin, which is active against Gram‐positive strains of Staphylococci , Enterococci , Streptococci , Pneumococci , Listeria , Corynebacterium , and Clostridia and currently, is generally used to treat the MRSA‐caused infections [3] poses a major problem in therapy, [4] making the need for new antibiotics more relevant than ever. Such a situation causes the vulnerability of society by resistant pathogens and outbreaks of dangerous diseases.…”

Antimicrobial Activity of Manganese(I) Tricarbonyl Complexes Bearing 1,2,3-Triazole Ligands

“…In fact, one of the most representative dominant examples in medicinal organometallic chemistry is ferroquine, an effective antimalarial drug [8]. However, in contrast to the significant advances in the development of organometallics as anticancer [9][10][11] and antimalarial drugs [8,[12][13][14] the development of organometallic antibacterial agents has received little attention. Only recently a number of organometallic complexes of Au [10,14], Mn [15,16], Ru [17], Rh [18,19], and Ir [18][19][20][21] have been explored as potential antimicrobial drugs.…”

Computer Aid Screening for Potential Antimalarial Choroquinone Compounds as Covid 19 Utilizing Computational Calculations and Molecular Docking Study

“…Because of that, the scientific community is striving to investigate many different mechanisms to interfere with the virus' metabolism. Consequently, in recent clinical trials against COVID-19 several antiviral drugs used with patients with similar viral infections to antimalarial drugs, such chloroquine (I), quinine (II) and amodiaquine (III) in malaria treatment is common (dos Santos Chagas et al, 2019;Kwofie et al, 2020). Also the hydroxychloroquine (IV) has approved drug for malaria disease treatment via the FDA was explored as a medication for SARS-CoV-2.…”