Review of cellular mechanotransduction

Wang, Ning

doi:10.1088/1361-6463/aa6e18

Cited by 137 publications

(131 citation statements)

References 102 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…Cells are mechanically connected to their surroundings by integrins and other mechanoresponsive cell surface proteins [9]. In turn, these mechanoresponsive cell surface proteins are connected to the cytoskeleton, which remodels in response to chemical and mechanical signalling (reviewed in [10]). Cytoskeletal remodeling controls the shape of the cell, the nucleus, and even chromatin organization [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Jacobson

Perry

Long

et al. 2018

Preprint

View full text Add to dashboard Cite

BackgroundMammalian cells are flexible and can rapidly change shape when they contract, adhere, or migrate. Their nucleus must be stiff enough to withstand cytoskeletal forces, but flexible enough to remodel as the cell changes shape. This is particularly important for cells migrating through constricted space, where the nuclear shape must change in order to fit through the constriction. This occurs many times in the life cycle of a neutrophil, which must protect its chromatin from damage and disruption associated with migration.

show abstract

Section: Introductionmentioning

confidence: 99%

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Jacobson

Perry

Long

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…These behaviors are well characterized in viscoelastic polymeric materials, which exhibit both fluid-like (viscous) and solid-like (elastic) properties. Thus, cells are often characterized as viscoelastic (18). However, unlike standard polymers, cells can actively adapt their stress state via actomyosin contraction and cytoskeletal remodeling, which could produce viscoelastic-like stress relaxation and hysteresis.…”

Section: Introductionmentioning

confidence: 99%

Architecture-Dependent Anisotropic Hysteresis in Smooth Muscle Cells

Win

Buksa

Alford

2018

Biophysical Journal

View full text Add to dashboard Cite

Cells within mechanically dynamic tissues like arteries are exposed to ever-changing forces and deformations. In some pathologies, like aneurysms, complex loads may alter how cells transduce forces, driving maladaptive growth and remodeling. Here, we aimed to determine the dynamic mechanical properties of vascular smooth muscle cells (VSMCs) under biaxial load. Using cellular micro-biaxial stretching microscopy, we measured the large-strain anisotropic stress-strain hysteresis of VSMCs and found that hysteresis is strongly dependent on load orientation and actin organization. Most notably, under some cyclic loads, we found that VSMCs with elongated in-vivo-like architectures display a hysteresis loop that is reverse to what is traditionally measured in polymers, with unloading stresses greater than loading stresses. This reverse hysteresis could not be replicated using a quasilinear viscoelasticity model, but we developed a Hill-type active fiber model that can describe the experimentally observed hysteresis. These results suggest that cells in highly organized tissues, like arteries, can have strongly anisotropic responses to complex loads, which could have important implications in understanding pathological mechanotransduction.

show abstract

“…The mechanotransduction process by which MSCs sense a mechanical signal at the cell membrane and translate it into a particular biological response remains one of the most fundamental questions of mechanobiology . Proposed mechanisms include activation of stretch‐activated ion channels or Integrin receptors which have been shown to mediate chondrocyte mechanotransduction .…”

Section: Discussionmentioning

confidence: 99%

Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell‐based cartilage tissue engineering

Remya

Nair

2020

Engineering Reports

View full text Add to dashboard Cite

Stem cell-based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs. In the present study, stem cell-seeded constructs were subjected to a dynamic compression of 10% strain, 1 Hz, 4 hours/1 hour each for 7 days. Integrin and Integrin-associated protein expression was evaluated using real-time PCR to elucidate the possible mechanotransduction pathway. Matrix remodeling was analyzed by evaluating chondrocyte-specific extracellular matrix genes as well as by expression of matrix metalloproteinases. The results suggest that dynamic compression significantly influences chondrogenesis by enhancing the expression of chondrocyte-specific extracellular matrix genes. The results also propose the involvement of Integrin-mediated signaling pathways in the mechanotransduction events on biomechanical stimuli-assisted chondrogenesis of stem cells.

show abstract

Review of cellular mechanotransduction

Cited by 137 publications

References 102 publications

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Architecture-Dependent Anisotropic Hysteresis in Smooth Muscle Cells

Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell‐based cartilage tissue engineering

Contact Info

Product

Resources

About