2019
DOI: 10.4172/0974-276x.1000493
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Review of Computational Prediction of Competing Endogenous RNA

Abstract: MicroRNAs (miRNAs) are the gene regulatory molecules that bind to microRNA response elements (MREs) in the 3' untranslated regions (UTRs) of mRNAs. The repressive activity of miRNA is counteracted by "miRNA sponges" or "competing endogenous RNAs (ceRNAs)" termed because of its competing nature of sequestering miRNA's effect. The ceRNAs with multiple MREs for a miRNA interact more, resulting in a regulatory gene network layer. The perturbation of ceRNA network causes various diseases including cancer. This disc… Show more

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References 94 publications
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