Review of conditioning regimens for haplo-identical donor transplants using post-transplant cyclophosphamide in recipients of G-CSF mobilised peripheral stem cell

Patil, Sushrut; Potter, Victoria; Mohty, Mohamad

doi:10.1016/j.ctrv.2020.102071

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…A very recent review summarized the various conditioning regimens used for HLA-haploidentical HCT. 110 Retrospective comparisons of results from different centers have suggested comparable outcomes with HLA-haploidentical related versus UCB grafts. In contrast, two recent prospective, randomized trials indicated better outcomes with HLA-haploidentical grafts compared to UCB transplants.…”

Section: Current Trendsmentioning

confidence: 99%

History of hematopoietic cell transplantation: challenges and progress

Granot

Storb

2020

haematol

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After more than 60 years of research in allogeneic hematopoietic cell transplantation (HCT), this therapy has advanced from one that was declared dead in the 1960s to a standard treatment of otherwise fatal malignant and non-malignant blood diseases. To date, close to 1.5 million hematopoietic cell transplants have been performed in more than 1,500 transplantation centers worldwide. This review will highlight the enormous efforts by numerous investigators throughout the world who have brought the experimental field of HCT to clinical reality, examine ongoing challenges, and provide insights for the future.

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Section: Current Trendsmentioning

confidence: 99%

History of hematopoietic cell transplantation: challenges and progress

Granot

Storb

2020

haematol

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“…On the contrary, haploidentical transplantation was seldom performed until the mid-2000s, but it accounted for 45.9% of all alternative donor transplants in 2018 in Korea (data provided by the Korean Blood and Marrow Transplantation Nurses Society). These trends are largely attributed to recent advances in haploidentical transplantation using post-transplant cyclophosphamide, which has proved effective in preventing severe graftversus-host disease (GVHD) without the need for ex vivo T-cell depletion [17][18][19]. In addition, a haploidentical donor is usually rapidly available, and an adequate cell number is guaranteed in most cases.…”

Section: Haploidentical Transplantation Versus Cbtmentioning

confidence: 99%

Strategies to enhance graft performance in cord blood transplantation

Yoo

2021

Precis Future Med

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Umbilical cord blood (CB) serves as one of the alternative donor sources for hematopoietic stem cell transplantation (HSCT) in those patients lacking a matched related donor. However, the relatively high incidence of engraftment failure and/or delayed engraftment following cord blood transplantation (CBT) has been a major obstacle against its success. The usage of two CB units has made CBT possible in adults when a single CB unit with an adequate cell number is lacking, but it failed to demonstrate any beneficial effect in children and adolescents. In recent years, unmanipulated haploidentical graft has been replacing CB owing to its rapid availability along with low incidence of acute and chronic graft-versus-host disease due to the usage of post-transplant cyclophosphamide. Given this situation, overcoming the engraftment related issues is crucial in order for CBT to remain a realistic alternative of allogeneic HSCT. This review discusses the engraftment-related issues in CBT and recent advances to overcome those, highlighting the role of conditioning, ex vivo CB stem cell expansion, and cotransplantation of mesenchymal stem/stromal cells.

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The current landscape: Allogeneic hematopoietic stem cell transplant for acute lymphoblastic leukemia

Prockop

2023

Best Practice & Research Clinical Haematology

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Review of conditioning regimens for haplo-identical donor transplants using post-transplant cyclophosphamide in recipients of G-CSF mobilised peripheral stem cell

Cited by 3 publications

References 24 publications

History of hematopoietic cell transplantation: challenges and progress

History of hematopoietic cell transplantation: challenges and progress

Strategies to enhance graft performance in cord blood transplantation

The current landscape: Allogeneic hematopoietic stem cell transplant for acute lymphoblastic leukemia

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