Review of Contemporary Gel-Forming Agents in the Technology of Dosage Forms

Анурова, М. Н.; Бахрушина, Е. О.; Демина, Н. Б.

doi:10.1007/s11094-015-1342-5

Cited by 24 publications

(16 citation statements)

References 8 publications

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“…[79][80][81] These stimuli exist in organisms, highlighting the possible suitability of such polymers for the development of controlled release and bioadhesive systems as they have stimuli-induced viscosity. [82][83][84][85] Mucoadhesion of thermosensitive gels and LCs can be explained by their rheological properties.…”

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confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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“…The study is aimed at studying the properties of biopolymer gelling agents and determining the composition of the future dosage form. The gel samples were obtained by dispersing the biopolymer in a portion of purified water (at 80 °С temperature for alginates), after swelling it was brought to required volume and mixed [4,5].…”

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confidence: 99%

Development of the Composition of the Biopolymer Base for Nasal Gel

et al. 2020

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In many cases the nasal cavity is the gateway for the infection; it necessitates the development of a drug for nasal administration with antiviral, adsorptive and protective properties. Gels were chosen as an optimal dosage form. The study is aimed at studying the properties of biopolymer gelling agents and determining the composition of the future dosage form. Materials and methods Gel samples with 3, 4 and 5% concentrations were prepared using the following gelling agents: sodium alginate Protanal CR8223, Protanal CR8133, Manucol LKХ (FMC BioPolymer) and xanthan gum GrinstedXanthan (DuPontDanisco), Xanthural 180 (CP Kelco). Adsorption and osmotic activity, bioadhesion and thermostability of the samples were determined. Results Basing on the totality of the obtained results, 3 compositions prospective for the dosage form development were selected: xanthan gums (particle size 180pm) from various manufacturers: Grinsted Xanthan 3 and 4% concentrations, Xanthural 180 5% concentration. These compositions possess high adsorption activity (25.06; 21.35; 20.6 g respectively), optimal osmotic activity (155, 171, 100%) and have significant bioadhesion (28.4421; 22.7237; 30.2835 N) that allows the drug to stay in the nasal cavity for a long period of time. All selected compositions demonstrated good high-temperature stability. Conclusion The obtained data shows prospects of applying the samples for the development of nasal gel with an immunobiological substance.

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“…Полоксамеры в научной литературе фигурируют под различными торговыми наименованиями (Pluronic/Lutrol/Kolliphor (BASF), Synperonic (Croda), Antarox (Rhodia)), а также существует специальная номенклатура этих полимеров, связывающая название с составом. Трехзначный код, фигурирующий в тор-говых наименованиях этих полимеров, связан с моле-кулярной массой ядра полиоксипропилена и процент-ным содержанием полиоксиэтена в полимере [2], что, в свою очередь, являются определяющими факторами для гелеобразования -полимеры с более высокой мо-лекулярной массой оказывают более выраженный гелеобразующий эффект при более низких концен-трациях [3].…”

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“…Все полоксамеры, кроме Poloxamer 124, являются твердыми веществами и представляют собой мелко-дисперстный гранулированный порошок белого цве-та, не имеющий вкуса и запаха, pH 10% растворов находится в диапазоне 5,0-7,5 [3,4]. Полоксамеры растворимы в воде, полярных и неполярных органи-ческих растворителях.…”

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“…Несмотря на очевидные преимущества, моноком-понентные гели на основе полоксамеров обладают и рядом недостатков: высокими окклюзионными свой-ствами, сравнительно низкими температурой гелеоб-разования и пределом текучести, средней осмотиче-ской активностью, низкой мукоадгезивной способно-стью и очень низкой адсорбционной активностью [3,4,5,6]. Как было сказано выше, в сухом виде полок-самеры не обладают выраженным вкусом и запахом, однако гелевые композиции с высоким содержанием полимера зачастую требуют коррекции органолепти-ческих показателей, при применении их орально, пе-рорально или интраназально.…”

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